Introduction：Basic information about CAS 56-94-0|Demecarium bromide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Demecarium bromide |
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| CAS Number | 56-94-0 | Molecular Weight | 716.588 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C32H52Br2N4O4 | Melting Point | 164 - 170ºC |
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| MSDS | / | Flash Point | / |
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Names
| Name | demecarium bromide |
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| Synonym | More Synonyms |
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Demecarium bromide BiologicalActivity
| Description | Demecarium Bromide (BC-48) is a potent cholinesterase inhibitor, with an apparent affinity (Kiapp) of 0.15 μM[1]. Demecarium Bromide (BC-48) is used as a glaucoma agent[2]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>AChE |
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| Target | Kiapp: 0.15 μM (Cholinesterase)[1] |
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| In Vivo | Demecarium Bromide (0.125 and 0.5%) causes long-term miosis and decreases intraocular pressure (IOP) in beagles with both normotensive eyes and inherited glaucoma[1]. |
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| References | [1]. Brown JH, et al. Activation and blockade of cardiac muscarinic receptors by endogenous acetylcholine and cholinesterase inhibitors. J Pharmacol Exp Ther. 1982 Oct;223(1):20-4. [2]. Gum GG, et al. Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma. Am J Vet Res. 1993 Feb;54(2):287-93. |
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Chemical & Physical Properties
| Melting Point | 164 - 170ºC |
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| Molecular Formula | C32H52Br2N4O4 |
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| Molecular Weight | 716.588 |
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| Exact Mass | 714.235535 |
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| PSA | 59.08000 |
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| LogP | 0.77020 |
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| InChIKey | YHKBUDZECQDYBR-UHFFFAOYSA-L |
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| SMILES | CN(CCCCCCCCCCN(C)C(=O)Oc1cccc([N+](C)(C)C)c1)C(=O)Oc1cccc([N+](C)(C)C)c1.[Br-].[Br-] |
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| Storage condition | 2-8℃ |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- BR3130000
- CHEMICAL NAME :
- Ammonium, (m-hydroxyphenyl)trimethyl-, bromide, decamethylenebis(methylcarbamate)
- CAS REGISTRY NUMBER :
- 56-94-0
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C32-H52-N4-O4.2Br
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6490 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 1,168,1967
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 29 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 128,307,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 24500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 1,168,1967 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3186 No. of Facilities: 9 (estimated) No. of Industries: 2 No. of Occupations: 9 No. of Employees: 3239 (estimated) No. of Female Employees: 1168 (estimated)
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Safety Information
| Safety Phrases | S22-S26-S36/37-S36/37/39 |
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| RIDADR | 3077 |
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| WGK Germany | 3 |
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| Packaging Group | III |
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| Hazard Class | 9 |
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Synonyms
| Tosmilen |
| 3,3'-{1,10-Decanediylbis[(methylcarbamoyl)oxy]}bis(N,N,N-trimethylanilinium) dibromide |
| Visumiotic |
| Demekastigmine bromide |
| 3,3'-{Decane-1,10-diylbis[(methylcarbamoyl)oxy]}bis(N,N,N-trimethylanilinium) dibromide |
| Tonilen |
| trimethyl-[3-[methyl-[10-[methyl-[3-(trimethylazaniumyl)phenoxy]carbonylamino]decyl]carbamoyl]oxyphenyl]azanium,dibromide |
| 3,3'-[1,10-Decanediylbis[(methylimino)carbonyloxy]]bis[N,N,N-trimethylbenzenaminium]dibromide |
| Benzenaminium, 3,3'-[1,10-decanediylbis[(methylimino)carbonyloxy]]bis[N,N,N-trimethyl-, bromide (1:2) |
| Humorsol |
| Tosmicil |
| decamethylenebis[m-dimethylaminophenyl n-methylcarbamate] dimethobromide |
| Decamethylenebis[N-methylcarbamic Acid m-Dimethylaminophenyl Ester] Bromidethylate |
| Tosmilene |
| EINECS 200-301-9 |
| Demecarium bromide |
| N,N'-Bis[3-trimethylammoniumphenoxycarbonyl]-N,N'-dimethyldecamethylenediamine Dibromide |
| Frumtosnil |
| Visumatic |
