Introduction：Basic information about CAS 6665-67-4|4',5-Dihydroxyflavone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4',5-Dihydroxyflavone |
|---|
| CAS Number | 6665-67-4 | Molecular Weight | 254.238 |
|---|
| Density | 1.4±0.1 g/cm3 | Boiling Point | 486.0±45.0 °C at 760 mmHg |
|---|
| Molecular Formula | C15H10O4 | Melting Point | 239-240ºC |
|---|
| MSDS | / | Flash Point | 190.0±22.2 °C |
|---|
Names
| Name | 5-hydroxy-2-(4-hydroxyphenyl)chromen-4-one |
|---|
| Synonym | More Synonyms |
|---|
4',5-Dihydroxyflavone BiologicalActivity
| Description | 4',5-Dihydroxyflavone is a soybean LOX-1 and yeast α-Glucosidase inhibitor, with an Ki of 102.6 μM for soybean LOX-1 and an IC50 of 66 μM for yeast α-glucosidase. |
|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>5-LipoxygenaseResearch Areas >>Others |
|---|
| Target | Ki: 102.6 μM (LOX-1)[1]. IC50: 66 μM (α-glucosidase)[2]. |
|---|
| References | [1]. Ribeiro D, et al. Inhibition of LOX by flavonoids: a structure-activity relationship study. Eur J Med Chem. 2014 Jan 24;72:137-45. [2]. Proença C, et al. α-Glucosidase inhibition by flavonoids: an in vitro and in silico structure-activity relationship study. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1216-1228. |
|---|
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|
| Boiling Point | 486.0±45.0 °C at 760 mmHg |
|---|
| Melting Point | 239-240ºC |
|---|
| Molecular Formula | C15H10O4 |
|---|
| Molecular Weight | 254.238 |
|---|
| Flash Point | 190.0±22.2 °C |
|---|
| Exact Mass | 254.057907 |
|---|
| PSA | 70.67000 |
|---|
| LogP | 2.32 |
|---|
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
|---|
| Index of Refraction | 1.699 |
|---|
| InChIKey | OKRNDQLCMXUCGG-UHFFFAOYSA-N |
|---|
| SMILES | O=c1cc(-c2ccc(O)cc2)oc2cccc(O)c12 |
|---|
| Storage condition | 2-8℃ |
|---|
Safety Information
Customs
| HS Code | 2914501900 |
|---|
| Summary | 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
|---|
Synonyms
| 4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)- |
| 4',5-Dihydroxyflavone |
| 5-Hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one |
| 4',5-dihydroxy flavone |
| 5,4'-Dihydroxyflavone |
