Introduction：Basic information about CAS 62-32-8|n-methyldopamine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | n-methyldopamine hydrochloride |
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| CAS Number | 62-32-8 | Molecular Weight | 203.666 |
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| Density | / | Boiling Point | 328.6ºC at 760 mmHg |
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| Molecular Formula | C9H14ClNO2 | Melting Point | 174-176ºC |
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| MSDS | / | Flash Point | 154.3ºC |
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Names
| Name | 4-[2-(methylamino)ethyl]benzene-1,2-diol,hydrochloride |
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| Synonym | More Synonyms |
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n-methyldopamine hydrochloride BiologicalActivity
| Description | N-Methyldopamine hydrochloride is a precursor of adrenaline in the adrenal medulla. N-Methyldopamine hydrochloride is a modification of the dopamine (DA), and retains agonist activity at the DA1 receptor. N-Methyldopamine hydrochloride remains capable of universal surface coating and secondary reactions using the surface catechols. N-Methyldopamine hydrochloride can be used for heart failure research[1][2][3]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
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| Target | D1 Receptor |
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| In Vitro | N-Methyldopamine hydrochloride shows highly improved surface coating properties, and exhibits an accelerated coating rate. N-Methyldopamine hydrochloride coating makes solid surface cell adhesion possible, and postfunctionalization of the coating is also possible[1]. |
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| References | [1]. Kim Y, et al. Effect of N-Methylation on Dopamine Surface Chemistry. Langmuir. 2022 May 24;38(20):6404-6410. [2]. Laduron P. N-Methyldopamine (epinine), a precursor of adrenaline in the adrenal medulla. Arch Int Pharmacodyn Ther. 1972 Apr;196:Suppl 196:304-. [3]. Rajfer SI, et al. Effects of long-term therapy with oral ibopamine on resting hemodynamics and exercise capacity in patients with heart failure: relationship to the generation of N-methyldopamine and to plasma norepinephrine levels. Circulation. 1986 Apr;73(4):740-8. |
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Chemical & Physical Properties
| Boiling Point | 328.6ºC at 760 mmHg |
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| Melting Point | 174-176ºC |
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| Molecular Formula | C9H14ClNO2 |
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| Molecular Weight | 203.666 |
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| Flash Point | 154.3ºC |
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| Exact Mass | 203.071304 |
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| PSA | 52.49000 |
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| LogP | 2.05260 |
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| Appearance of Characters | solid | white |
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| InChIKey | JCDRZCWRRLKLTB-UHFFFAOYSA-N |
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| SMILES | CNCCc1ccc(O)c(O)c1.Cl |
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| Storage condition | 2-8°C |
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| Water Solubility | H2O: soluble |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UX1925000
- CHEMICAL NAME :
- Pyrocatechol, 4-(2-(methylamino)ethyl)-, hydrochloride
- CAS REGISTRY NUMBER :
- 62-32-8
- LAST UPDATED :
- 199012
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C9-H13-N-O2.Cl-H
- MOLECULAR WEIGHT :
- 203.69
- WISWESSER LINE NOTATION :
- QR BQ D2M1 &GH
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 71,62,1941
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 212 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,1194,1975 *** REVIEWS *** TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 9,389,1931
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Safety Information
| Hazard Codes | Xi |
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| WGK Germany | 3 |
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| RTECS | UX1925000 |
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| HS Code | 2922299090 |
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Customs
| HS Code | 2922299090 |
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| Summary | 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| 4-[2-(Methylamino)ethyl]benzene-1,2-diol hydrochloride (1:1) |
| Pyrocatechol, 4-[2- (methylamino)ethyl]-, hydrochloride |
| Ephinine hydrochloride |
| 1,2-Benzenediol, 4-[2-(methylamino)ethyl]-, hydrochloride (1:1) |
| MFCD00035074 |
| 1,2-Benzenediol, 4-[2-(methylamino)ethyl]-hydrochloride |
| 1,2-Benzenediol, 4-[2- (methylamino)ethyl]-, hydrochloride |
| N-Methyldopamine hydrochloride |
| 3,4-Dihydroxyphenylethylmethylamine hydrochloride |
| EPININE HCl |
| 3,4-dihydroxyphenethylmethylammonium chloride |
| 1,2-Benzenediol, 4-(2-(methylamino)ethyl)-, hydrochloride (9CI) |
| Methyldopamine hydrochloride |
| EINECS 200-528-3 |
| 4-[2-(Methylamino)ethyl]-1,2-benzenediol hydrochloride (1:1) |
| Deoxyepinephrine hydrochloride |
| Epinine hydrochloride |
