Introduction：Basic information about CAS 62992-61-4|Etersalate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Etersalate |
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| CAS Number | 62992-61-4 | Molecular Weight | 357.35700 |
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| Density | 1.263g/cm3 | Boiling Point | 561.8ºC at 760 mmHg |
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| Molecular Formula | C19H19NO6 | Melting Point | / |
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| MSDS | / | Flash Point | 293.6ºC |
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Names
| Name | 2-(4-acetamidophenoxy)ethyl 2-acetyloxybenzoate |
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| Synonym | More Synonyms |
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Etersalate BiologicalActivity
| Description | Etersalate inhibits platelet function and decreases thromboxane A2 (TXA2) levels. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Prostaglandin ReceptorResearch Areas >>Cardiovascular Disease |
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| Target | TXA2 |
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| In Vitro | Ex vivo antiplatelet properties of Etersalate and its effects on serum thromboxane A2 (TXA2) levels and prostaglandin I2 (PGI2) generation are studied in human volunteers at two levels of oral dosing. Etersalate inhibits at the lower dosage platelet function and decreased TXA2 levels, but PGI2 generation from rat aortic rings is stimulated when incubated with plasma from Etersalate-treated donors. Blood coagulation parameters remain within normal values. Etersalate administration can act on platelet arachidonate metabolism at a different level than that of the cyclooxygenase pathway[1]. |
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| References | [1]. Ortega MP, et al. Effect of etersalate on human platelet responsiveness. A study in healthy volunteers. Arzneimittelforschung. 1987 Feb;37(2):214-7. |
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Chemical & Physical Properties
| Density | 1.263g/cm3 |
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| Boiling Point | 561.8ºC at 760 mmHg |
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| Molecular Formula | C19H19NO6 |
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| Molecular Weight | 357.35700 |
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| Flash Point | 293.6ºC |
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| Exact Mass | 357.12100 |
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| PSA | 90.93000 |
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| LogP | 2.87910 |
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| Index of Refraction | 1.582 |
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| InChIKey | PXBFSRVXEKCBFP-UHFFFAOYSA-N |
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| SMILES | CC(=O)Nc1ccc(OCCOC(=O)c2ccccc2OC(C)=O)cc1 |
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| Storage condition | 2-8℃ |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DG0929000
- CHEMICAL NAME :
- Benzoic acid, 2-(acetyloxy)-, 2-(4-(acetylamino)phenoxy)ethyl ester
- CAS REGISTRY NUMBER :
- 62992-61-4
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C19-H19-N-O6
- MOLECULAR WEIGHT :
- 357.39
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD10 - Lethal Dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4014921
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AFTOD7 Archivos de Farmacologia y Toxicologia. (Universidad Complutense, Facultad de Medicina, Departamento Coordinado de Farmacologia, Ciudad Universitaria, Madrid 3, Spain) V.1- 1975- Volume(issue)/page/year: 4,167,1978
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Safety Information
Customs
| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| Etersalate |
| Daital |
| EINECS 263-780-3 |
| Eterilate |
| Etherylate |
| Eterylate |
