CAS 88847-89-6|8-hydroxy-2'-deoxyguanosine
| Common Name | 8-hydroxy-2'-deoxyguanosine | ||
|---|---|---|---|
| CAS Number | 88847-89-6 | Molecular Weight | 283.241 |
| Density | 2.3±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C10H13N5O5 | Melting Point | 217-220ºC |
| MSDS | USA | Flash Point | / |
Names
| Name | 8-hydroxy-2'-deoxyguanosine |
|---|---|
| Synonym | More Synonyms |
8-hydroxy-2'-deoxyguanosine BiologicalActivity
| Description | 8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis. |
|---|---|
| Related Catalog | Research Areas >>CancerNatural Products >>Others |
| Target | Human Endogenous Metabolite |
| In Vitro | 8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a good biomarker for risk assessment of various cancers and degenerative diseases. The biomarker 8-Hydroxy-2'-deoxyguanosine (8-OHdG) or 8-oxodG has been a pivotal marker for measuring the effect of endogenous oxidative damage to DNA and as a factor of initiation and promotion of carcinogenesis. The biomarker has been used to estimate the DNA damage in humans after exposure to cancer-causing agents, such as tobacco smoke, asbestos fibers, heavy metals, and polycyclic aromatic hydrocarbons[1]. |
| References | [1]. Valavanidis A, et al. 8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Apr;27(2):120-39. |
Chemical & Physical Properties
| Density | 2.3±0.1 g/cm3 |
|---|---|
| Melting Point | 217-220ºC |
| Molecular Formula | C10H13N5O5 |
| Molecular Weight | 283.241 |
| Exact Mass | 283.091675 |
| PSA | 159.51000 |
| LogP | -1.32 |
| Index of Refraction | 1.955 |
| InChIKey | HCAJQHYUCKICQH-VPENINKCSA-N |
| SMILES | Nc1nc2c([nH]c(=O)n2C2CC(O)C(CO)O2)c(=O)[nH]1 |
| Storage condition | 2-8°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | MF8782675 |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles142
More Articles| Complement-dependent NADPH oxidase enzyme activation in renal ischemia/reperfusion injury. Free Radic. Biol. Med. 74 , 263-73, (2014) NADPH oxidase plays a central role in mediating oxidative stress during heart, liver, and lung ischemia/reperfusion injury, but limited information is available about NADPH oxidase in renal ischemia/r... | |
| Axitinib induces DNA damage response leading to senescence, mitotic catastrophe, and increased NK cell recognition in human renal carcinoma cells. Oncotarget 6 , 36245-59, (2015) Tyrosine kinase inhibitors (TKIs) including axitinib have been introduced in the treatment of renal cell carcinoma (RCC) because of their anti-angiogenic properties. However, no evidence are presently... | |
| Effect of long-term human exposure to environmental heavy metals on the expression of detoxification and DNA repair genes. Environ. Pollut. 181 , 226-32, (2013) The present study was designed to evaluate the influence of long-term environmental human exposure to three heavy metals, lead (Pb), cadmium (Cd), and mercury (Hg), on the expression of detoxifying, x... |
Synonyms
| 2'-deoxy-7,8-dihydro-8-oxo-guanosine |
| MFCD00210311 |
| 2'-Deoxy-8-oxo-7,8-dihydroguanosine |
| 7,8-Dihydro-8-oxo-2'-deoxyguanosine |
| 2'-Deoxy-8-oxoguanosine |
| 8-Oxo-7,8-dihydrodeoxyguanosine |
| 2'-Deoxy-8-oxo-D-guanosine |
| 8-Oxodeoxyguanosine |
| guanosine, 2'-deoxy-8-oxo- |
| 2'-Deoxy-8-hydroxyguanosine |
| 8-oxo-7,8-dihydro-2'-deoxiguanosine |
| Guanosine, 2'-deoxy-8-hydroxy- |
| 8-oxo-7-hydrodeoxyguanosine |
| 8-hydroxydeoxyguanosine |
| 8-HYDROXY-2'-DEOXYGUANOSINE |
| 8-Hydroxy-2’-deoxyguanosine |
| 8-oxo-7,8-dihydro-2'-deoxyguanosine |
| 2'-Deoxy-7,8-dihydro-8-oxoguanosine |
