Introduction：Basic information about CAS 5634-41-3|parapenzolate bromide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | parapenzolate bromide |
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| CAS Number | 5634-41-3 | Molecular Weight | 420.34000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C21H26BrNO3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | (1,1-dimethylpiperidin-1-ium-4-yl) 2-hydroxy-2,2-diphenylacetate,bromide |
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| Synonym | More Synonyms |
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parapenzolate bromide BiologicalActivity
| Description | Parapenzolate bromide, an antispasmodic, is an orally active mAChR antagonist. Parapenzolate bromide is an anticholinergic agent[1][2]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>mAChRSignaling Pathways >>GPCR/G Protein >>mAChRResearch Areas >>Neurological Disease |
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| In Vivo | Parapenzolate bromide (10 mg/kg, p.o. or i.v.) shows a significant analgesic effect in mice[1]. Parapenzolate bromide (0.5 mg/kg, i.v.) exhibits a spasmolytic activity in isolated gall bladder from guinea pigs[2]. Animal Model: Mice[1] Dosage: 10 mg/kg Administration: Oral administration (p.o.) or intravenous injection (i.v.) Result: Prolonged the time until death in convulsive mice. Animal Model: Guinea pigs[2] Dosage: 0.5 mg/kg Administration: Intravenous injection (i.v.) Result: Antagonized contractions induced by acetylcholine (100 μg/kg, i.v.) |
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| References | [1]. Paris, J., et al. Effect of parapenzolate bromide on the contractility of the gall bladder and sphincter of Oddi. Therapie (1968), 23(3), 609-18. [2]. Ishimura Yasuko, et al. Pharmacological studies on parapenzolate bromide. 1. Pharmacological studies. Shikoku Igaku Zasshi (1970), 26(1), 43-51. |
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Chemical & Physical Properties
| Molecular Formula | C21H26BrNO3 |
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| Molecular Weight | 420.34000 |
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| Exact Mass | 419.11000 |
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| PSA | 46.53000 |
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| InChIKey | NHTZWXHFTDRAEO-UHFFFAOYSA-M |
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| SMILES | C[N+]1(C)CCC(OC(=O)C(O)(c2ccccc2)c2ccccc2)CC1.[Br-] |
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Synonyms
| Bromuro de parapenzolato |
| Bromure de parapenzolate |
| Parapenzolate bromide |
| Parapenzolati bromidum |
| Parapenzolatbromid |
| 4-benziloyloxy-1,1-dimethyl-piperidinium,bromide |
| 4-[2-hydroxy(diphenyl)acetoxy]-1,1-dimethylpiperidinium bromide |
