Introduction：Basic information about CAS 105-20-4|Betazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Betazole |
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| CAS Number | 105-20-4 | Molecular Weight | 111.14500 |
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| Density | 1.14g/cm3 | Boiling Point | 284.1ºC at 760mmHg |
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| Molecular Formula | C5H9N3 | Melting Point | 25°C |
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| MSDS | / | Flash Point | 150.3ºC |
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Names
| Name | betazole |
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| Synonym | More Synonyms |
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Betazole BiologicalActivity
| Description | Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity[1][2][3]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Metabolic DiseaseSignaling Pathways >>GPCR/G Protein >>Histamine Receptor |
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| Target | H2 Receptor |
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| In Vitro | Betazole (Ametazole) is a weak histamine agonist with relative selectivity towards H2 receptors and only minimal H1 activity. Betazole induces gastric inhibitory polypeptide (GIP) secretion[1]. |
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| References | [1]. Maples MD, Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg. 1981;47(12):519-521. [2]. Spitz IM, Betazole-induced GIP secretion is not mediated by gastric HCl. Metabolism. 1982;31(4):380-382. [3]. CLAYMAN CB,. A simple oral gastric secretory stimulant (betazole hydrochloride). JAMA. 1961;175:908-909. |
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Chemical & Physical Properties
| Density | 1.14g/cm3 |
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| Boiling Point | 284.1ºC at 760mmHg |
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| Melting Point | 25°C |
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| Molecular Formula | C5H9N3 |
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| Molecular Weight | 111.14500 |
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| Flash Point | 150.3ºC |
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| Exact Mass | 111.08000 |
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| PSA | 54.70000 |
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| LogP | 0.61120 |
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| Vapour Pressure | 0.00303mmHg at 25°C |
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| Index of Refraction | 1.567 |
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| InChIKey | JXDFEQONERDKSS-UHFFFAOYSA-N |
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| SMILES | NCCc1ccn[nH]1 |
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Safety Information
Customs
| HS Code | 2933199090 |
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| Summary | 2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2-(1(2)H-Pyrazol-3-yl)-aethylamin |
| 3-(2-aminoethyl)pyrazole |
| Ametazole |
| 3-(2-Aminoethyl)-1H-pyrazole |
| 3-(2-Aminoethyl)pyrazol |
| 2-(1H-pyrazol-5-yl)ethanamine(SALTDATA: FREE) |
| 2-(1(2)H-pyrazol-3-yl)-ethylamine |
| EINECS 203-278-3 |
