CAS 2348-82-5|Lawsone methyl ether

Introduction：Basic information about CAS 2348-82-5|Lawsone methyl ether, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Lawsone methyl ether BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles9
8. Synonyms

Common Name	Lawsone methyl ether
CAS Number	2348-82-5	Molecular Weight	188.17900
Density	1.28g/cm3	Boiling Point	339.8ºC at 760mmHg
Molecular Formula	C₁₁H₈O₃	Melting Point	184-187ºC(lit.)
MSDS	ChineseUSA	Flash Point	152.7ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	2-methoxy-1,4-naphthoquinone
Synonym	More Synonyms

Lawsone methyl ether BiologicalActivity

Description	Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. and Swertia calycina, exhibits potent antifungal and antibacterial activities[1].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Anti-infection >>FungalSignaling Pathways >>Anti-infection >>Bacterial
In Vitro	The value of both minimal inhibitory concentration and minimal fungicidal concentration of Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) against Candida was 1.25 lg⁄ml[1].
References	[1]. Sritrairat N, et al. Antifungal activity of lawsone methyl ether in comparison with chlorhexidine. J Oral Pathol Med. 2011 Jan;40(1):90-6.

Chemical & Physical Properties

Density	1.28g/cm3
Boiling Point	339.8ºC at 760mmHg
Melting Point	184-187ºC(lit.)
Molecular Formula	C₁₁H₈O₃
Molecular Weight	188.17900
Flash Point	152.7ºC
Exact Mass	188.04700
PSA	43.37000
LogP	1.59590
Vapour Pressure	8.98E-05mmHg at 25°C
Index of Refraction	1.589
InChIKey	OBGBGHKYJAOXRR-UHFFFAOYSA-N
SMILES	COC1=CC(=O)c2ccccc2C1=O
Storage condition	-20℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL8960000

CHEMICAL NAME :: 1,4-Naphthoquinone, 2-methoxy-

CAS REGISTRY NUMBER :: 2348-82-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H8-O3

MOLECULAR WEIGHT :: 188.19

WISWESSER LINE NOTATION :: L66 BV EVJ CO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,570,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	S26;S36
RIDADR	NONH for all modes of transport
RTECS	QL8960000
HS Code	2914690090

Customs

HS Code	2914690090
Summary	2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles9

2-Methoxy-1,4-naphthoquinone (MNQ) induces apoptosis of A549 lung adenocarcinoma cells via oxidation-triggered JNK and p38 MAPK signaling pathways.

Life Sci. 135 , 158-64, (2015)

The compound 2-methoxy-1,4-naphthoquinone (MNQ) was previously shown to be cytotoxic against several cancer cell lines, but its mode of action is poorly understood. In this study, we aimed to explore ...

Anti-gastric adenocarcinoma activity of 2-Methoxy-1,4-naphthoquinone, an anti-Helicobacter pylori compound from Impatiens balsamina L.

Fitoterapia 83(8) , 1336-44, (2012)

2-Methoxy-1,4-naphthoquinone (MeONQ) from Impatiens balsamina L. exhibited strong anti-H. pylori activity in our previous study. In this study, we investigated the cytotoxicity of MeONQ against gastri...

Effects of the compounds 2-methoxynaphthoquinone, 2-propoxynaphthoquinone, and 2-isopropoxynaphthoquinone on ecdysone 20-monooxygenase activity.

Arch. Insect Biochem. Physiol. 66(1) , 45-52, (2007)

The effects of the natural compound 2-methoxy-1,4-naphthoquinone, isolated from the leaves of Impatiens glandulifera and the synthetic compounds 2-propoxy-1,4-naphthoquinone and 2-isopropoxy-1,4-napht...

Synonyms

2-Methoxy-p-naphthoquinone

1,4-Naphthalenedione,2-methoxy

2-methoxy-1,4-naphthalenequinone

2-methoxynaphthalene-1,4-dione

2-Methoxy-[1,4]naphthoquinone

2-methoxyl-1,4-naphthoquinone

2-Methoxynaphthoquinone

1,4-NAPHTHOQUINONE,2-METHOXY

MFCD00019539

2-Methoxy-1,4-naphthalenedione

Methoxy-1,4-naphthochinin

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