CAS 1225-65-6|(dimethyl)[10H-pyrido[3,2-b][1,4]benzothiazine-10-propyl]ammonium chloride

Introduction：Basic information about CAS 1225-65-6|(dimethyl)[10H-pyrido[3,2-b][1,4]benzothiazine-10-propyl]ammonium chloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Synonyms

Common Name	(dimethyl)[10H-pyrido[3,2-b][1,4]benzothiazine-10-propyl]ammonium chloride
CAS Number	1225-65-6	Molecular Weight	321.86800
Density	/	Boiling Point	/
Molecular Formula	C₁₆H₂₀ClN₃S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	N,N-dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-ylpropan-1-amine,hydrochloride
Synonym	More Synonyms

BiologicalActivity

Description	Prothipendyl hydrochloride is an orally active agent that can be used in the study of mental symptoms in the aged (e.g. anxiety)[1].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
References	[1]. J F FLEETWOOD, et al. The Treatment of Mental Symptoms in the Aged With Prothipendyl (Tolnate). J Coll Gen Pract. 1964 Sep;8(2):262-6.

Chemical & Physical Properties

Molecular Formula	C₁₆H₂₀ClN₃S
Molecular Weight	321.86800
Exact Mass	321.10700
PSA	41.43000
LogP	1.15470
InChIKey	CQJSAKJMCVSEGU-UHFFFAOYSA-N
SMILES	CN(C)CCCN1c2ccccc2Sc2cccnc21.Cl

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU8750000

CHEMICAL NAME :: 10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(3-(dimethylamino)propyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 1225-65-6

LAST UPDATED :: 199012

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H19-N3-S.Cl-H

MOLECULAR WEIGHT :: 321.90

WISWESSER LINE NOTATION :: T C666 BN DN ISJ B1Y1&N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 610 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,292,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 115 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,292,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1323 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,292,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,292,1972

Synonyms

(3-Benzo[b]pyrido[2,3-e][1,4]thiazin-10-yl-propyl)-dimethyl-amin,Monohydrochlorid

Dominal hydrochloride

Dominal forte

(dimethyl)(10H-pyrido[3,2-b][1,4]benzothiazine-10-propyl)ammonium chloride

N,N-dimethyl-10H-pyrido[3,2-b][1,4]benzothiazine-10-propanamine,monohydrochloride

10-(3-Dimethylaminopropyl)-1-azaphenothiazine hydrochloride

Tolnate

Prothipendyl HCl

(3-benzo[b]pyrido[2,3-e][1,4]thiazin-10-yl-propyl)-dimethyl-amine,monohydrochloride

Prothipendyl hydrochloride

Azacon

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