Introduction：Basic information about CAS 191744-13-5|CX 614, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | CX 614 |
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| CAS Number | 191744-13-5 | Molecular Weight | 247.24700 |
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| Density | 1.45g/cm3 | Boiling Point | 473.8ºC at 760 mmHg |
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| Molecular Formula | C13H13NO4 | Melting Point | / |
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| MSDS | / | Flash Point | 240.3ºC |
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Names
| Name | cx614 |
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| Synonym | More Synonyms |
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CX 614 BiologicalActivity
| Description | CX614 is a positive variant modulator of AMPA receptors that enhances excitatory postsynaptic potentials (amplitude and duration) by blocking and slowing the inactivation of responses to glutamate and automatically evokes excitatory postsynaptic currents in neuronal cultures. CX614 can be used in the study of psychiatric disorders such as depression[1][2]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR |
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| In Vitro | CX614 (100 μM) 在 HEK293 细胞中，促进谷氨酸表观亲和力并增加谷氨酸诱发的内向电流，增加 3.5 和 10 mM 的谷氨酸反应峰值[1]。 |
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| In Vivo | CX614 (1 or 10 mg/kg, i.p., twice a day) 明显增加 P5 小鼠海马和皮层的 BDNF mRNA，证实了 AMPA 受体的正向异生调节剂对海马 BDNF mRNA 水平的上调作用[2]。 |
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| References | [1]. Wei Dai, et al. The Impact and Mechanism of a Novel Allosteric AMPA Receptor Modulator LCX001 on Protection Against Respiratory Depression in Rodents. Front Pharmacol. 2019 Feb 19;10:105. [2]. Eleni Dicou, et al. Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain. Brain Res. 2003 Apr 25;970(1-2):221-5. |
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Chemical & Physical Properties
| Density | 1.45g/cm3 |
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| Boiling Point | 473.8ºC at 760 mmHg |
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| Molecular Formula | C13H13NO4 |
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| Molecular Weight | 247.24700 |
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| Flash Point | 240.3ºC |
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| Exact Mass | 247.08400 |
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| PSA | 48.00000 |
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| LogP | 1.35020 |
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| Vapour Pressure | 3.82E-09mmHg at 25°C |
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| Index of Refraction | 1.651 |
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| InChIKey | RQEPVMAYUINZRE-UHFFFAOYSA-N |
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| SMILES | O=C1c2cc3c(cc2OC2CCCN12)OCCO3 |
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| Storage condition | 2-8°C |
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Safety Information
Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| CX 614 |
| BDP 37 |
| 2,3,6a,7,8,9-Hexahydro-11H-1,4-dioxino[2,3-g]pyrrolo[2,1-b][1,3]benzoxazin-11-one |
| 6a,7,8,9-Tetrahydro-2H-[1,4]dioxino[2',3':4,5]benzo[1,2-e]pyrrolo[2,1-b][1,3]oxazin-11(3H)-one |
| LiD 37 |
| CX-614 |
