Introduction：Basic information about CAS 27425-92-9|m-PEG10-alcohol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | m-PEG10-alcohol |
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| CAS Number | 27425-92-9 | Molecular Weight | 472.568 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 524.3±45.0 °C at 760 mmHg |
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| Molecular Formula | C21H44O11 | Melting Point | 19ºC |
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| MSDS | / | Flash Point | 270.9±28.7 °C |
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Names
| Name | 2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol |
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| Synonym | More Synonyms |
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m-PEG10-alcohol BiologicalActivity
| Description | m-PEG10-alcohol (Decaethylene glycol monomethyl ether) is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. Nnochiri Ekwuribe, et al. Calcitonin drug-oligomer conjugates, and uses thereof. US20040091452A1. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 524.3±45.0 °C at 760 mmHg |
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| Melting Point | 19ºC |
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| Molecular Formula | C21H44O11 |
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| Molecular Weight | 472.568 |
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| Flash Point | 270.9±28.7 °C |
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| Exact Mass | 472.288361 |
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| PSA | 112.53000 |
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| LogP | -4.02 |
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| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
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| Index of Refraction | 1.455 |
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| InChIKey | YMBLPWKGRIGDBP-UHFFFAOYSA-N |
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| SMILES | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO |
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Safety Information
Customs
| HS Code | 2909499000 |
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| Summary | 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0% |
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Synonyms
| O-methyl-decaethylene glycol |
| O-Methyl-decaaethylenglykol |
| 2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontan-31-ol |
| Decaethylene Glycol Monomethyl Ether |
