CAS 87981-04-2|Maleimide-C10-NHS ester

Introduction：Basic information about CAS 87981-04-2|Maleimide-C10-NHS ester, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Maleimide-C10-NHS ester BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Maleimide-C10-NHS ester
CAS Number	87981-04-2	Molecular Weight	378.419
Density	1.3±0.1 g/cm3	Boiling Point	520.4±42.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₆N₂O₆	Melting Point	/
MSDS	/	Flash Point	268.5±27.9 °C

Names

Name	11-Maleimidoundecanoic Acid N-Succinimidyl Ester
Synonym	More Synonyms

Maleimide-C10-NHS ester BiologicalActivity

Description	Maleimide-C10-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker
Target	Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	520.4±42.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₆N₂O₆
Molecular Weight	378.419
Flash Point	268.5±27.9 °C
Exact Mass	378.179077
PSA	101.06000
LogP	1.84
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.552
InChIKey	SGNVTRHWJGTNKV-UHFFFAOYSA-N
SMILES	O=C(CCCCCCCCCCN1C(=O)C=CC1=O)ON1C(=O)CCC1=O

Safety Information

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36
WGK Germany	3

Synonyms

(2,5-dioxopyrrolidin-1-yl) 11-(2,5-dioxopyrrol-1-yl)undecanoate

1-{11-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-11-oxoundecyl}-1H-pyrrole-2,5-dione

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