CAS 7496-02-8|Chrysene, 6-nitro-

Introduction：Basic information about CAS 7496-02-8|Chrysene, 6-nitro-, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
4. Safety Information
5. Articles27
6. Synonyms

Common Name	Chrysene, 6-nitro-
CAS Number	7496-02-8	Molecular Weight	273.28500
Density	1.342g/cm3	Boiling Point	505ºC at 760 mmHg
Molecular Formula	C₁₈H₁₁NO₂	Melting Point	220ºC (dec.)(lit.)
MSDS	ChineseUSA	Flash Point	252.5ºC
Symbol	GHS07, GHS08	Signal Word	Danger

Names

Name	6-Nitrochrysene
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.342g/cm3
Boiling Point	505ºC at 760 mmHg
Melting Point	220ºC (dec.)(lit.)
Molecular Formula	C₁₈H₁₁NO₂
Molecular Weight	273.28500
Flash Point	252.5ºC
Exact Mass	273.07900
PSA	45.82000
LogP	5.57760
Index of Refraction	1.791
InChIKey	UAWLTQJFZUYROA-UHFFFAOYSA-N
SMILES	O=[N+]([O-])c1cc2c3ccccc3ccc2c2ccccc12
Storage condition	2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GC1930000

CHEMICAL NAME :: Chrysene, 6-nitro-

CAS REGISTRY NUMBER :: 7496-02-8

BEILSTEIN REFERENCE NO. :: 2134652

LAST UPDATED :: 199612

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C18-H11-N-O2

MOLECULAR WEIGHT :: 273.30

WISWESSER LINE NOTATION :: L E6 B666J DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9163 ug/kg/2W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 279,153,1992 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,267,1989 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,267,1989 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,267,1989

Safety Information

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302 + H312 + H332-H340-H350
Precautionary Statements	P201-P261-P280-P301 + P312 + P330-P308 + P313
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T
Risk Phrases	45-46-20/21/22
Safety Phrases	S22;S45;S53;S36/S37/S39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	GC1930000

Articles27

Polycyclic nitroarenes (nitro-PAHs) as biomarkers of exposure to diesel exhaust.

Mutat. Res. 441(1) , 135-44, (1999)

Diesel exhaust contains numerous genotoxic carcinogens. It is essentially unknown to which extent this source contributes to the total load of these chemicals in humans. One possible approach to the p...

Synthesis of anti-1,2-dihydroxy-3,4-epoxy-1,2,3, 4-tetrahydro-6-nitrochrysene and its reaction with 2'-deoxyguanosine- 5'-monophosphate, 2'-deoxyadenosine-5'-monophosphate, and calf thymus DNA in vitro.

Chem. Res. Toxicol. 13(11) , 1143-8, (2000)

The remarkable carcinogenic activity of 6-nitrochrysene (6-NC) in several animal models, and its environmental presence, suggest its potential importance with regard to human cancer development. Depen...

Genomic DNA sequencing of mRNA splicing mutants in the hprt gene of Chinese hamster ovary cells.

Environ. Mol. Mutagen. 25(2) , 85-96, (1995)

We have analyzed 41 mRNA-splicing mutants from the hypoxanthine-guanine phosphoribosyl-transferase (hprt) gene of Chinese hamster ovary (CHO) cells. Twenty-two of these mutants produced single cDNA PC...

Synonyms

6-nitrochrysene

MFCD00021179

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