CAS 482-70-2|Chimaphilin

Introduction：Basic information about CAS 482-70-2|Chimaphilin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chimaphilin BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Chimaphilin
CAS Number	482-70-2	Molecular Weight	186.21
Density	1.187g/cm3	Boiling Point	346.8ºC at 760mmHg
Molecular Formula	C₁₂H₁₀O₂	Melting Point	/
MSDS	/	Flash Point	130.1ºC

Names

Name	2,7-dimethylnaphthalene-1,4-dione
Synonym	More Synonyms

Chimaphilin BiologicalActivity

Description	Chimaphilin is an IGF-1R inhibitor (IC50: 0.086 μM). Chimaphilin has antifungal, antioxidant and anticancer activities. Chimaphilin inhibits the growth of both drug-sensitive and drug-resistant osteosarcoma cell lines. Chimaphilin can induce cancer cell apoptosis. Chimaphilin is a main component of pyrola[1][2].
Related Catalog	Research Areas >>CancerResearch Areas >>InfectionResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Protein Tyrosine Kinase/RTK >>IGF-1R
Target	0.086 μM (IGF-1R)[1]
References	[1]. Daqian W, et al. Chimaphilin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines through insulin-like growth factor-I receptor (IGF-IR) signaling. Chem Biol Interact. 2015 Jul 25;237:25-30. [2]. Ma WD, et al. Chimaphilin induces apoptosis in human breast cancer MCF-7 cells through a ROS-mediated mitochondrial pathway. Food Chem Toxicol. 2014 Aug;70:1-8.

Chemical & Physical Properties

Density	1.187g/cm3
Boiling Point	346.8ºC at 760mmHg
Molecular Formula	C₁₂H₁₀O₂
Molecular Weight	186.21
Flash Point	130.1ºC
Exact Mass	186.06800
PSA	34.14000
LogP	2.32030
Vapour Pressure	5.6E-05mmHg at 25°C
Index of Refraction	1.583
InChIKey	YZACZIYTZCJVSN-UHFFFAOYSA-N
SMILES	CC1=CC(=O)c2ccc(C)cc2C1=O

Synonyms

1,2,7-dimethyl

2,7-dimethylnaphthoquinone

2,7-Dimethyl-1,4-naphthoquinone

Chimaphylin

2,7-dimethylnaphtho-1,4-quinone

Chimaphilin

1.4-Dioxo-2.7-dimethyl-1.4-dihydro-naphthalin

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