CAS 70-18-8|Glutathione
Introduction：Basic information about CAS 70-18-8|Glutathione, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Glutathione | ||
|---|---|---|---|
| CAS Number | 70-18-8 | Molecular Weight | 307.323 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 754.5±60.0 °C at 760 mmHg |
| Molecular Formula | C10H17N3O6S | Melting Point | 182-192ºC |
| MSDS | ChineseUSA | Flash Point | 410.1±32.9 °C |
Names
| Name | Glutathione |
|---|---|
| Synonym | More Synonyms |
Glutathione BiologicalActivity
| Description | L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseResearch Areas >>Inflammation/ImmunologyBiochemical Assay ReagentsResearch Areas >>CancerResearch Areas >>Neurological DiseaseNatural Products >>Others |
| Target | Human Endogenous Metabolite |
| In Vitro | L-Glutathione reduced is a non-protein thiol widely exists in living cells. L-Glutathione reduced plays important biological functions in the organism, including protein and DNA synthesis, enzyme activity, metabolism and cell protection. L-Glutathione reduced is capable of scavenging oxygen-derived free radicals and is established to be a marker of oxidative stress[1]. |
| References | [1]. Pereira-Rodrigues N, et al. Electrocatalytic activity of cobalt phthalocyanine CoPc adsorbed on a graphite electrode for the oxidation of reduced L-glutathione (GSH) and the reduction of its disulfide (GSSG) at physiological pH. Bioelectrochemistry. 2007 Jan;70(1):147-54. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 754.5±60.0 °C at 760 mmHg |
| Melting Point | 182-192ºC |
| Molecular Formula | C10H17N3O6S |
| Molecular Weight | 307.323 |
| Flash Point | 410.1±32.9 °C |
| Exact Mass | 307.083801 |
| PSA | 197.62000 |
| LogP | -0.87 |
| Vapour Pressure | 0.0±5.5 mmHg at 25°C |
| Index of Refraction | 1.572 |
| InChIKey | RWSXRVCMGQZWBV-WDSKDSINSA-N |
| SMILES | NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4020 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2238 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1250 mg/kg
- SEX/DURATION :
- female 1-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
MUTATION DATA - TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 10 mmol/L
- REFERENCE :
- CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 31,265,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83371 No. of Facilities: 174 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1744 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83371 No. of Facilities: 238 (estimated) No. of Industries: 1 No. of Occupations: 7 No. of Employees: 3078 (estimated) No. of Female Employees: 2121 (estimated)
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 10 mmol/L
- REFERENCE :
- CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 31,265,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83371 No. of Facilities: 174 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1744 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83371 No. of Facilities: 238 (estimated) No. of Industries: 1 No. of Occupations: 7 No. of Employees: 3078 (estimated) No. of Female Employees: 2121 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R68 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | MC0556000 |
| HS Code | 2930909090 |
Customs
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| L-Glutathione Reduced |
| Tathion |
| L-Norvaline, 5-[[(1R,2Z)-2-[(carboxymethyl)imino]-2-hydroxy-1-(mercaptomethyl)ethyl]imino]-5-hydroxy-, (5Z)- |
| (5Z)-5-({(1Z,2R)-1-[(Carboxymethyl)imino]-1-hydroxy-3-sulfanyl-2-propanyl}imino)-5-hydroxy-L-norvaline |
| Deltathione |
| Glycine, N- (N-L-γ-glutamyl-L-cysteinyl)- |
| L-γ-Glutamyl-L-cysteinylglycine |
| Copren |
| Glycine, L-γ-glutamyl-L-cysteinyl- |
| Isethion |
| Glutathione reduced |
| GSH |
| Glutathione |
| Reduced glutathione |
| (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid |
| L-γ-Glutamyl-L-cysteiylglycin |
| Glutathiol |
| MFCD00065939 |
| EINECS 200-725-4 |
| (2S)-2-Amino-5-({(2R)-1-[(carboxymethyl)amino]-1-oxo-3-sulfanyl-2-propanyl}amino)-5-oxopentanoic acid |
| Glutathione-SH |
| N-(N-L-g-Glutamyl-L-cysteinyl)glycine |
| Glutinal |
| L-Glutathione |
| γ-glutamyl-cysteinyl-glycine |
