Introduction：Basic information about CAS 26839-75-8|Timolol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Timolol |
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| CAS Number | 26839-75-8 | Molecular Weight | 316.42000 |
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| Density | 1.224 g/cm3 | Boiling Point | 487.2ºC at 760 mmHg |
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| Molecular Formula | C13H24N4O3S | Melting Point | 71.5 - 72.5ºC |
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| MSDS | / | Flash Point | 248.5ºC |
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Names
| Name | (S)-timolol (anhydrous) |
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| Synonym | More Synonyms |
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Timolol BiologicalActivity
| Description | Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect[1][2]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Inflammation/Immunology |
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| In Vitro | Timolol can significantly prevent the increased lipid peroxidation level of the heart from diabetic rats. Timolol can induce a well-balanced ratio between oxidative stress and antioxidant defense system in the diabetic animals, can have an important cardioprotection against diabetes-induced ERS and associated apoptotic effects[3]. |
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| In Vivo | Timolol has a cardioprotective effect via inhibition of ERS response in diabetic rats[3]. Animal Model: Experimental diabetes model: 3-month old male Wistar rats[3]. Dosage: 5 mg/kg Administration: Timolol (5 mg/kg daily for 12-week) Result: Showed cardioprotective effect. |
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| References | [1]. James Barnes; Majid Moshirfar. Timolol. [2]. E. Ansari, et al. Treatment of open-angle glaucoma and ocular hypertension with preservative-free tafuprost/timolol fxed-dose combination therapy: 6 case reports and clinical outcomes. BMC Ophthalmol. 2022 Apr 2;22(1):152. [3]. Figen Amber Cicek, et al. Beta-blocker timolol alleviates hyperglycemia-induced cardiac damage via inhibition of endoplasmic reticulum stress. J Bioenerg Biomembr |
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Chemical & Physical Properties
| Density | 1.224 g/cm3 |
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| Boiling Point | 487.2ºC at 760 mmHg |
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| Melting Point | 71.5 - 72.5ºC |
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| Molecular Formula | C13H24N4O3S |
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| Molecular Weight | 316.42000 |
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| Flash Point | 248.5ºC |
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| Exact Mass | 316.15700 |
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| PSA | 107.98000 |
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| LogP | 0.95840 |
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| Vapour Pressure | 2.62E-10mmHg at 25°C |
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| Index of Refraction | 1.548 |
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| InChIKey | BLJRIMJGRPQVNF-JTQLQIEISA-N |
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| SMILES | CC(C)(C)NCC(O)COc1nsnc1N1CCOCC1 |
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Synonyms
| (S)-thymolol |
| timolol |
| Istalol |
| (S)-timolol |
| (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol |
| Optimol |
| (S)-(-)-3-(3-tert-butylamino-2-hydroxypropoxy)-4-(N-morpholino)-1,2,5-thiadiazole |
| Timacar |
| (S)-(-)-(1-tert-butylamino)-3-(4-morpholino-1,2,5-thiadiazol-3-yloxy)-2-propanol |
| Timoptic |
| Blocadren |
| S(-)-Timolol maleate |
| Betimol |
| Timoptol |
| EINECS 248-032-6 |
| MFCD00864565 |
| Timopic |
