CAS 29110-47-2|Guanfacine

Introduction：Basic information about CAS 29110-47-2|Guanfacine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Guanfacine BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Guanfacine
CAS Number	29110-47-2	Molecular Weight	246.093
Density	1.5±0.1 g/cm3	Boiling Point	424.9ºC at 760 mmHg
Molecular Formula	C₉H₉Cl₂N₃O	Melting Point	227-230?C
MSDS	/	Flash Point	210.8ºC

Names

Name	N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide
Synonym	More Synonyms

Guanfacine BiologicalActivity

Description	Guanfacine is a selective α2A receptor agonist.Target: α2A ReceptorGuanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone [1, 2].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Neurological Disease
References	[1]. Kolar, D., et al., Treatment of adults with attention-deficit/hyperactivity disorder. Neuropsychiatr Dis Treat, 2008. 4(2): p. 389-403. [2]. Zwieten, P.v., M. Thoolen, and P. Timmermans, The pharmacology of centrally acting antihypertensive drugs. British journal of clinical pharmacology, 1983. 15(Supplement s4): p. 455S-462S.

Description

Guanfacine is a selective α2A receptor agonist.Target: α2A ReceptorGuanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone [1, 2].

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Neurological Disease

References

[1]. Kolar, D., et al., Treatment of adults with attention-deficit/hyperactivity disorder. Neuropsychiatr Dis Treat, 2008. 4(2): p. 389-403.

[2]. Zwieten, P.v., M. Thoolen, and P. Timmermans, The pharmacology of centrally acting antihypertensive drugs. British journal of clinical pharmacology, 1983. 15(Supplement s4): p. 455S-462S.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	424.9ºC at 760 mmHg
Melting Point	227-230?C
Molecular Formula	C₉H₉Cl₂N₃O
Molecular Weight	246.093
Flash Point	210.8ºC
Exact Mass	245.012268
PSA	78.97000
LogP	1.12
Vapour Pressure	2E-07mmHg at 25°C
Index of Refraction	1.635
InChIKey	INJOMKTZOLKMBF-UHFFFAOYSA-N
SMILES	NC(N)=NC(=O)Cc1c(Cl)cccc1Cl
Storage condition	Refrigerator

Safety Information

HS Code	2925290090

Customs

HS Code	2925290090
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Synonyms

Intuniv

Guanfacine

Guanfacina [INN-Spanish]

[(2,6-Dichlorophenyl)acetyl]guanidine

Guanfacine [INN:BAN]

Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-

N-amidino-2-(2,6-dichlorophenyl)acetamide

N-Carbamimidoyl-2-(2,6-dichlorophenyl)acetamide

Estulic

Lon798

Guanfacina

N-(aminoiminomethyl)-2,6-dichlorobenzeneacetamide

Guanfacinum

Guanfacinum [INN-Latin]

BS 100-141

Tenex

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