CAS 7659-95-2|betanin

Introduction：Basic information about CAS 7659-95-2|betanin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. betanin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	betanin
CAS Number	7659-95-2	Molecular Weight	550.469
Density	1.8±0.1 g/cm3	Boiling Point	983.5±75.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₆N₂O₁₃	Melting Point	/
MSDS	/	Flash Point	548.6±37.1 °C

Names

Name	betanin
Synonym	More Synonyms

betanin BiologicalActivity

Description	Betanin has potent antioxidant and anti-inflammatory effect, that could inhibit peroxynitrite (ONOO-), with an IC50 of 19.2 μM. Betanin is a red glycoside obtained from beets that can be used as colorant.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic DiseaseNatural Products >>Saccharides and Glycosides
Target	IC50: 19.2 μM (ONOO-)[1].
In Vitro	Betanin is a representative constituent of red beetroot betacyanins, could inhibit peroxynitrite (ONOO-), with an IC50 of 19.2 μM[1]. Betanin also has anti-inflammatory, anti-proliferative effects, nephroprotective activity, cardioprotective activity, strong, antioxidant and angiotensin converting enzyme (ACE) inhibitory activity[2]. Another study is also indicated the protective effect of Betanin against high glucose induced rat renal epithelial cell fibrosis and matrix accumulation, major features of diabetic nephropathy (DN)[2].
In Vivo	Betanin can inhibit the fructose-induced diabetic cardiac fibrosis and paraquat induced acute kidney toxicity[2]. The co-administration of Betanin (20 mg/kg b.w.) to diabetic rats prevent significantly the raise of glucose level and also reverse the levels of insulin compared with untreated diabetic rats. Interestingly diabetic rats treated with Betanin (20 mg/kg b.w.) and glibenclamide portray the significant changes in the body weight compared to diabetic control. HbA1c levels significantly increases in diabetic rats and when treated with Betanin as well as glibenclamide. Treatment with Betanin as well as glibenlamide to STZ-NA induces diabetic rat’s elicit significant decreases in those levels when compared with diabetic control rats[3].
Animal Admin	Rats[3] Healthy adult Male albino Wistar strain (Rattus norvegicus, 90-120 days of age) are used in the current study. After the successful induction of experimental diabetes, the rats are divided into four groups each comprising a minimum of six rats a total of 30 rats (18 diabetic surviving rats, 12 normal rats). Betanin is administered via oral intubation to the experimental rats using a gavage needle daily for a period of 30 days. Group 1: Normal Control rats. Group 2: Rats treated with Betanin (20 mg/kg b.w.) alone. Group 3: Diabetic Control rats. Group 4: Rats treated with STZ-NA by i.p. and Betanin (20 mg/kg b.w.). Group 5: Rats treated with STZ-NA by i.p. and glibenclamide (600 μg/kg b.w.)[3].
References	[1]. Sakihama Y, et al. Beetroot betalain inhibits peroxynitrite-mediated tyrosine nitration and DNA strand cleavage. Free Radic Res. 2012 Jan;46(1):93-9. [2]. Sutariya B, et al. Betanin, isolated from fruits of Opuntia elatior Mill attenuates renal fibrosis in diabetic rats through regulating oxidative stress and TGF-β pathway. J Ethnopharmacol. 2017 Feb 23;198:432-443. [3]. Indumathi D, et al. Betanin exhibits significant potential as an antihyperglycemic and attenuating the glycoprotein components in streptozotocin-nicotinamide-induced experimental rats. Toxicol Mech Methods. 2018 Sep;28(7):547-554.

Chemical & Physical Properties

Density	1.8±0.1 g/cm3
Boiling Point	983.5±75.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₆N₂O₁₃
Molecular Weight	550.469
Flash Point	548.6±37.1 °C
Exact Mass	550.143494
PSA	249.38000
LogP	-4.49
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.740

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US7968100

CHEMICAL NAME :: 2,6-Pyridinedicarboxylic acid, 4-(2-(2-carboxy-5-(beta-D-glucopyranosyloxy)-2,3-dihy dro-6- hydroxy-1H-indol-1-yl)ethenyl)-2,3-dihydro-, (S-(R*,R*))-

CAS REGISTRY NUMBER :: 7659-95-2

LAST UPDATED :: 199112

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C24-H26-N2-O13

MOLECULAR WEIGHT :: 550.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 17200 gm/L

REFERENCE :: CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 55,203,1990

Safety Information

Safety Phrases	S24/25
RIDADR	2261.0
RTECS	US7968100
Hazard Class	6.1
HS Code	3203001990

Customs

HS Code	3203001990

Synonyms

(s-(r*,r*))--dihydro-6-hydroxy-1h-indol-1-yl)ethenyl)-3-dihydro

(Red Beet extract diluted with Dextrin)

Phytolaccanin

(2S)-4-{2-[(2S)-2-Carboxy-5-(β-D-glucopyranosyloxy)-6-hydroxy-2,3-dihydro-1H-indol-1-yl]vinyl}-2,3-dihydro-2,6-pyridinedicarboxylic acid

Beetroot Red

EINECS 231-628-5

2,6-Pyridinedicarboxylic acid, 4-[2-[(2S)-2-carboxy-5-(β-D-glucopyranosyloxy)-2,3-dihydro-6-hydroxy-1H-indol-1-yl]ethenyl]-2,3-dihydro-, (2S)-

Betanin (Red Beet extract diluted with Dextrin)

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