Introduction：Basic information about CAS 66036-77-9|H-D-Arg(NO2)-OH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | H-D-Arg(NO2)-OH |
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| CAS Number | 66036-77-9 | Molecular Weight | 219.199 |
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| Density | 1.7±0.1 g/cm3 | Boiling Point | 462.4±55.0 °C at 760 mmHg |
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| Molecular Formula | C6H13N5O4 | Melting Point | >220ºC |
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| MSDS | / | Flash Point | 233.5±31.5 °C |
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Names
| Name | (R)-2-Amino-5-(3-nitroguanidino)pentanoic acid |
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| Synonym | More Synonyms |
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H-D-Arg(NO2)-OH BiologicalActivity
| Description | N'-Nitro-D-arginine (NOLA), a nitric oxide synthesis inhibitor, also is a vasodilator that relaxes the smooth muscles and increases blood flow to the penis, improving erections. N'-Nitro-D-arginine also inhibits neutrophil migration by blocking receptors for tumour necrosis factor alpha (TNFα) and interleukin 8 (IL8) [1]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Immunology/Inflammation >>NO Synthase |
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| In Vivo | N'-Nitro-D-arginine (NOLA) (40 mg/ kg) produces a significant increase in systolic blood pressure in the chronic, awake, instrumented sheep model[1]. |
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| References | [1]. C K Narkowicz, et al. Delayed recovery from NG-nitro-L-arginine in the conscious sheep. Clin Exp Pharmacol Physiol. 1991 Dec;18(12):843-6. |
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Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
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| Boiling Point | 462.4±55.0 °C at 760 mmHg |
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| Melting Point | >220ºC |
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| Molecular Formula | C6H13N5O4 |
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| Molecular Weight | 219.199 |
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| Flash Point | 233.5±31.5 °C |
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| Exact Mass | 219.096756 |
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| PSA | 157.05000 |
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| LogP | -0.79 |
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| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
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| Index of Refraction | 1.638 |
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| InChIKey | MRAUNPAHJZDYCK-SCSAIBSYSA-N |
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| SMILES | NC(=NCCCC(N)C(=O)O)N[N+](=O)[O-] |
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| Storage condition | Store at RT. |
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | 22-36/37/38 |
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| Safety Phrases | 26-36 |
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| HS Code | 2925290090 |
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Customs
| HS Code | 2925290090 |
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| Summary | 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Synonyms
| MFCD00066013 |
| L-Ornithine, N-[(E)-imino(nitroamino)methyl]- |
| D-Ornithine, N-[amino(nitroamino)methylene]-, (E)- |
| N-ω-NITRO-L-ARGININE |
| (E)-N-[Amino(nitroamino)methylene]-D-ornithine |
| N'-Nitro-D-arginine |
| H-Arg(NO2)-OH |
| L-Ornithine, N5-(imino(nitroamino)methyl)- |
| N-(N-Nitrocarbamimidoyl)-L-ornithine |
| H-D-Arg(NO2)-OH |
| Ng-Nitro-D-arginine |
