CAS 6621-47-2|Perhexiline

Introduction：Basic information about CAS 6621-47-2|Perhexiline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NamePerhexiline
CAS Number6621-47-2Molecular Weight277.48800
Density/Boiling Point340ºC at 760 mmHg
Molecular FormulaC19H35NMelting Point/
MSDS/Flash Point164.5ºC

Names

Nameperhexiline
SynonymMore Synonyms

Perhexiline BiologicalActivity

DescriptionPerhexiline is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline induces mitochondrial dysfunction and apoptosis in hepatic cells. Perhexiline can cross the blood brain barrier (BBB) and shows anti-tumor activity. Perhexiline can be used in the research of cancers, and cardiovascular disease like angina[1][2][5].
Related CatalogSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>Cardiovascular Disease
In VitroPerhexiline (5-25 μM, 2-6 h) reduces cell viability in HepG2 cells[2]. Perhexiline (5-25 μM, 2-6 h) reduces cellular ATP content and Lactate dehydrogenase (LDH) release in HepG2 cells[2]. Perhexiline (20 μM, 2 h) activates caspase 3/7 in HepG2 cells[2]. Perhexiline (5-25 μM, 4 h) causes mitochondrial dysfunction in HepG2 cells[2]. Perhexiline (5 μM, 48 h) selectively induces massive apoptosis in CLL cells (high expression of CPT)[3]. Cell Viability Assay[2] Cell Line: HepG2 cells Concentration: 5, 10, 15, 25 μM Incubation Time: 2, 4, 6 h Result: Induced time- and concentration-dependent cytotoxicity in hepatic cells. Western Blot Analysis[2] Cell Line: HepG2 cells Concentration: 5, 10, 15, 25 μM Incubation Time: 2 h Result: Reduced Bcl-2 and Mcl-1 level, and increased Bad level.
In VivoPerhexiline (200 mg/kg, p.o., daily for 8 weeks) reduces peripheral neural function in female DA rats[4]. Perhexiline (80 mg/kg, oral gavage, for 3 days) demonstrates anti-tumor activity in glioblastoma mouse model[5]. Animal Model: Orthotopic glioblastoma mouse model[5] Dosage: 80 mg/kg Administration: Oral gavage, for 3 days. Result: Reduces tumor size (MR imaging) and improves in overall survival.

Chemical & Physical Properties

Boiling Point340ºC at 760 mmHg
Molecular FormulaC19H35N
Molecular Weight277.48800
Flash Point164.5ºC
Exact Mass277.27700
PSA12.03000
LogP5.62420

Synonyms

perhexilene
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