CAS 66521-38-8|Melatonin D5

Introduction：Basic information about CAS 66521-38-8|Melatonin D5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Melatonin D5 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Melatonin D5
CAS Number	66521-38-8	Molecular Weight	236.30300
Density	1.196g/cm3	Boiling Point	512.831ºC at 760 mmHg
Molecular Formula	C₁₃H₁₂D₄N₂O₂	Melting Point	117-118ºC
MSDS	/	Flash Point	263.951ºC

Names

Name	Melatonin-d4
Synonym	More Synonyms

Melatonin D5 BiologicalActivity

Description	Melatonin D5 is deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Neuronal Signaling >>Melatonin ReceptorSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>GPCR/G Protein >>Melatonin ReceptorResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Autophagy >>MitophagyResearch Areas >>Neurological Disease
References	[1]. Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665 [2]. Hu C, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1 [3]. Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31 [4]. Bu LJ, et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017 Feb 14;23(6):986-998.

Description

Melatonin D5 is deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4].

Related Catalog

Research Areas >>CancerSignaling Pathways >>Neuronal Signaling >>Melatonin ReceptorSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>GPCR/G Protein >>Melatonin ReceptorResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Autophagy >>MitophagyResearch Areas >>Neurological Disease

References

[1]. Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665

[2]. Hu C, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1

[3]. Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31

[4]. Bu LJ, et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017 Feb 14;23(6):986-998.

Chemical & Physical Properties

Density	1.196g/cm3
Boiling Point	512.831ºC at 760 mmHg
Melting Point	117-118ºC
Molecular Formula	C₁₃H₁₂D₄N₂O₂
Molecular Weight	236.30300
Flash Point	263.951ºC
Exact Mass	236.14600
PSA	54.12000
LogP	2.24600
Index of Refraction	1.6
InChIKey	DRLFMBDRBRZALE-NZLXMSDQSA-N
SMILES	COc1ccc2[nH]cc(CCNC(C)=O)c2c1
Storage condition	-20C

Synonyms

N-[1,1,2,2-tetradeuterio-2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide

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