CAS 69353-21-5|5-METHOXY-9-METHYL-2,3,3A,3A1,8,9,10,11-OCTAHYDRO-4-OXA-9-AZACYCLOOCTA[DEF]FLU

Introduction：Basic information about CAS 69353-21-5|5-METHOXY-9-METHYL-2,3,3A,3A1,8,9,10,11-OCTAHYDRO-4-OXA-9-AZACYCLOOCTA[DEF]FLU, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Synonyms

Common Name	5-METHOXY-9-METHYL-2,3,3A,3A1,8,9,10,11-OCTAHYDRO-4-OXA-9-AZACYCLOOCTA[DEF]FLUOREN-2-OL HYDROBROMIDE
CAS Number	69353-21-5	Molecular Weight	184.19100
Density	1.593 g/cm3	Boiling Point	630.4ºC at 760 mmHg
Molecular Formula	C₁₂H₈O₂	Melting Point	287ºC decomposes
MSDS	/	Flash Point	335ºC

Names

Name	galanthamine hydrobromide
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.593 g/cm3
Boiling Point	630.4ºC at 760 mmHg
Melting Point	287ºC decomposes
Molecular Formula	C₁₂H₈O₂
Molecular Weight	184.19100
Flash Point	335ºC
Exact Mass	184.05200
PSA	18.46000
LogP	3.58460
InChIKey	DKGIHQCMWKXHHR-UHFFFAOYSA-N
SMILES	Br.COc1ccc2c3c1OC1CC(O)C=C(CCN(C)C2)C31
Storage condition	−20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DF8075000

CHEMICAL NAME :: Benzofuro(4,3,2-efg)(2)benzazocin-6-ol, 1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-2-methyl-, hydrobromide

CAS REGISTRY NUMBER :: 69353-21-5

LAST UPDATED :: 199212

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C17-H21-N-O3.Br-H

MOLECULAR WEIGHT :: 368.31

WISWESSER LINE NOTATION :: T766 C6/CM B 2AC Q CX EN LO PUT&TTJ E1 JO1 OQ &EH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 32,301,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 32,301,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHABA8 Chemical Abstracts. (Chemical Abstracts Service, Box 3012, Columbus, OH 43210) V.1- 1907- Volume(issue)/page/year: 66,53993v,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 7,402,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15400 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 25,168,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5200 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - excitement Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,347,1961 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.05 mg/m3;Skin JAN 1993

Safety Information

Hazard Codes	T: Toxic;
Risk Phrases	R25
Safety Phrases	S45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	DF8075000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2942000000

Customs

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

2,3,3a,8,9,10,11,11b-Octahydro-5-methoxy-9-methylbenzofuro[4,3,2-efg][2]benzazocin-2-ol hydrobromide

2-benzylhexahydro-1H-isoindol-4(2H)-one

(3aS)-1-benzyl-5-ethoxy-3a,8-dimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole

(3aS)-4c-methoxy-3,8c-diphenyl-(3ar,5ac,9at,9bc)-hexahydro-[1,3]dioxino[4',5':5,6]pyrano[3,4-d]oxazole-2-thione

(3ARS,7ASR)-2-benzyl-4-perhydroisoindolone

11-Hydroxycephalotaxin

(3aS)-2-methoxy-(3arC4,14bc)-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[b][1,3]dioxolo[4',5':4,5]benzo[1,2-d]pyrrolo[1,2-a]azepine-1t,9t-diol

(3aS)-1-benzyl-5-ethoxy-3a,8-d methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole

(3aS)-1-benzyl-3a-methyl-1,2,3,3a,8,8a-tetrahydropyrrolo[2,3-b]indole-5-ol

(3aS)-4c-Methoxy-3,8c-diphenyl-(3ar,5ac,9at,9bc)-hexahydro-[1,3]dioxino[4',5':5,6]pyrano[3,4-d]oxazol-2-thion

(3aS)-1-benzyl-3a-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ol

11-hydroxycephalotaxine

Recommended......