CAS 210537-04-5|1,11b-Dihydro-11b-hydroxyMedicarpin

Introduction：Basic information about CAS 210537-04-5|1,11b-Dihydro-11b-hydroxyMedicarpin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 1,11b-Dihydro-11b-hydroxyMedicarpin BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	1,11b-Dihydro-11b-hydroxyMedicarpin
CAS Number	210537-04-5	Molecular Weight	288.295
Density	1.4±0.1 g/cm3	Boiling Point	490.0±45.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₆O₅	Melting Point	/
MSDS	/	Flash Point	185.8±22.2 °C

Names

Name	3-(2-Methyl-1,3-benzodioxol-2-yl)propanal
Synonym	More Synonyms

1,11b-Dihydro-11b-hydroxyMedicarpin BiologicalActivity

Description	1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative[1]. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways[2]. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice[3].
Related Catalog	Signaling Pathways >>Immunology/Inflammation >>Interleukin RelatedResearch Areas >>Inflammation/Immunology
References	[1]. Alejandro F.Barrero, et al. Pterocarpans from Ononis viscosa subsp. breviflora. Phytochemistry. 1998 May, 48 (1): 187-190. [2]. Manisha Dixit, et al. Medicarpin, a Natural Pterocarpan, Heals Cortical Bone Defect by Activation of Notch and Wnt Canonical Signaling Pathways. PLoS One. 2015 Dec 11;10(12):e0144541. [3]. Mohd Nizam Mansoori, et al. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Int Immunopharmacol. 2020 Feb 22;82:106299.

Description

1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative[1]. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways[2]. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice[3].

Related Catalog

Signaling Pathways >>Immunology/Inflammation >>Interleukin RelatedResearch Areas >>Inflammation/Immunology

References

[1]. Alejandro F.Barrero, et al. Pterocarpans from Ononis viscosa subsp. breviflora. Phytochemistry. 1998 May, 48 (1): 187-190.

[2]. Manisha Dixit, et al. Medicarpin, a Natural Pterocarpan, Heals Cortical Bone Defect by Activation of Notch and Wnt Canonical Signaling Pathways. PLoS One. 2015 Dec 11;10(12):e0144541.

[3]. Mohd Nizam Mansoori, et al. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Int Immunopharmacol. 2020 Feb 22;82:106299.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	490.0±45.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₆O₅
Molecular Weight	288.295
Flash Point	185.8±22.2 °C
Exact Mass	288.099762
PSA	64.99000
LogP	1.36
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.637
InChIKey	XIJBDLYFYFZZDS-APHBMKBZSA-N
SMILES	COc1ccc2c(c1)OC1C2COC2=CC(=O)CCC21O

Synonyms

(6aR,11aR,11bS)-11b-Hydroxy-9-methoxy-1,2,6,6a,11a,11b-hexahydro-3H-[1]benzofuro[3,2-c]chromen-3-one

3H-Benzofuro[3,2-c][1]benzopyran-3-one, 1,2,6,6a,11a,11b-hexahydro-11b-hydroxy-9-methoxy-, (6aR,11aR,11bS)-

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