CAS 376362-03-7|1-(4-Hydroxy-2-Methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)propane

Introduction：Basic information about CAS 376362-03-7|1-(4-Hydroxy-2-Methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)propane, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name1-(4-Hydroxy-2-Methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)propane
CAS Number376362-03-7Molecular Weight326.429
Density1.1±0.1 g/cm3Boiling Point490.3±40.0 °C at 760 mmHg
Molecular FormulaC21H26O3Melting Point/
MSDS/Flash Point250.3±27.3 °C

Names

Name4-[3-(4-Hydroxy-2-methoxyphenyl)propyl]-2-(3-methyl-2-buten-1-yl) phenol
SynonymMore Synonyms

BiologicalActivity

Description1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated from Broussonetia kazinoki, shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes[1].
Related CatalogSignaling Pathways >>Metabolic Enzyme/Protease >>PhosphataseResearch Areas >>Metabolic Disease
References

[1]. Jing-Jing Xue, et al. Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki. Fitoterapia. 2018 Oct;130:37-42.

Chemical & Physical Properties

Density1.1±0.1 g/cm3
Boiling Point490.3±40.0 °C at 760 mmHg
Molecular FormulaC21H26O3
Molecular Weight326.429
Flash Point250.3±27.3 °C
Exact Mass326.188202
PSA49.69000
LogP5.74
Vapour Pressure0.0±1.3 mmHg at 25°C
Index of Refraction1.581
InChIKeyTXWULZGRVGVEDI-UHFFFAOYSA-N
SMILESCOc1cc(O)ccc1CCCc1ccc(O)c(CC=C(C)C)c1

Safety Information

Hazard CodesXi

Synonyms

Phenol, 4-[3-(4-hydroxy-2-methoxyphenyl)propyl]-2-(3-methyl-2-buten-1-yl)-
4-[3-(4-Hydroxy-2-methoxyphenyl)propyl]-2-(3-methyl-2-buten-1-yl)phenol
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