CAS 53948-10-0|1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one

Introduction：Basic information about CAS 53948-10-0|1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one
CAS Number53948-10-0Molecular Weight309.316
Density1.3±0.1 g/cm3Boiling Point462.8±45.0 °C at 760 mmHg
Molecular FormulaC18H15NO4Melting Point/
MSDS/Flash Point233.7±28.7 °C

Names

Name1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one
SynonymMore Synonyms

BiologicalActivity

DescriptionAristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models[1].
Related CatalogSignaling Pathways >>Protein Tyrosine Kinase/RTK >>DYRKResearch Areas >>Inflammation/Immunology
References

[1]. Miri Choi, et al. Aristolactam BIII, a naturally derived DYRK1A inhibitor, rescues Down syndrome-related phenotypes. Phytomedicine. 2021 Nov:92:153695.  

Chemical & Physical Properties

Density1.3±0.1 g/cm3
Boiling Point462.8±45.0 °C at 760 mmHg
Molecular FormulaC18H15NO4
Molecular Weight309.316
Flash Point233.7±28.7 °C
Exact Mass309.100098
PSA60.28000
LogP3.23
Vapour Pressure0.0±1.1 mmHg at 25°C
Index of Refraction1.681
InChIKeyOQKGOEOSXXHWFQ-UHFFFAOYSA-N
SMILESCOc1ccc2cc3c4c(cc(OC)c(OC)c4c2c1)C(=O)N3

Safety Information

HS Code2933990090

Customs

HS Code2933990090
Summary2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

Dibenz[cd,f]indol-4(5H)-one, 1,2,9-trimethoxy-
3,4,6-trimethoxyaristolactame
aristolactam A II
Aristololactam B III
1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one
aristololactam A-II
Dibenz(cd,f)indol-4(5H)-one,2-hydroxy-1-methoxy
aristolactam BIII
CAS 97399-90-1|2-[(Trimethylsilyl)ethynyl]nicotinonitrile
CAS 112501-42-5|1-Hydroxy-2-methoxydibenzo[cd,f]indol-4(5H)-one
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