Introduction：Basic information about CAS 32884-36-9|Cajanin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cajanin |
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| CAS Number | 32884-36-9 | Molecular Weight | 300.263 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 605.5±55.0 °C at 760 mmHg |
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| Molecular Formula | C16H12O6 | Melting Point | / |
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| MSDS | / | Flash Point | 231.7±25.0 °C |
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Names
| Name | 3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxychromen-4-one |
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| Synonym | More Synonyms |
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Cajanin BiologicalActivity
| Description | Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis[1][2]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| In Vitro | Cajanin shows strong mitogenic as well as differentiation-promoting effects on osteoblasts[2]. Cajanin induces the phosphorylation of both Erk1/2 and Akt[2]. |
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| In Vivo | Cajanin (10 mg/kg, p.o.; daily for 30 consecutive days) increases the BMD levels in all anatomical regions of the skeleton studied in Sprague Dawley rats[1]. |
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| References | [1]. Netcharoensirisuk P, et al. Cajanin Suppresses Melanin Synthesis through Modulating MITF in Human Melanin-Producing Cells. Molecules. 2021 Oct 5;26(19):6040. [2]. Bhargavan B, et al. Methoxylated isoflavones, cajanin and isoformononetin, have non-estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signaling. J Cell Biochem. 2009 Oct 1;108(2):388-99. [3]. Wensaas AJ, et al. Fatty acid incubation of myotubes from humans with type 2 diabetes leads to enhanced release of beta-oxidation products because of impaired fatty acid oxidation: effects of tetradecylthioacetic acid and eicosapentaenoic acid. Diabetes. 2009 Mar;58(3):527-35. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 605.5±55.0 °C at 760 mmHg |
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| Molecular Formula | C16H12O6 |
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| Molecular Weight | 300.263 |
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| Flash Point | 231.7±25.0 °C |
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| Exact Mass | 300.063385 |
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| PSA | 100.13000 |
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| LogP | 3.57 |
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| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
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| Index of Refraction | 1.697 |
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| InChIKey | ALFNTRJPGFNJQV-UHFFFAOYSA-N |
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| SMILES | COc1cc(O)c2c(=O)c(-c3ccc(O)cc3O)coc2c1 |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2914509090 |
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Customs
| HS Code | 2914509090 |
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| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| 5,2',4'-Trihydroxy-7-methoxyisoflavone |
| Cajanin |
| 2',4',5-Trihydroxy-7-methoxyisoflavon |
| 4H-1-Benzopyran-4-one, 3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy- |
| 3-(2,4-Dihydroxyphenyl)-5-hydroxy-7-methoxy-4H-chromen-4-one |
| 2',4',5-trihydroxy-7-methoxyisoflavone |
