Introduction：Basic information about CAS 603-56-5|Chrysosplenetin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Chrysosplenetin |
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| CAS Number | 603-56-5 | Molecular Weight | 374.341 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 615.8±55.0 °C at 760 mmHg |
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| Molecular Formula | C19H18O8 | Melting Point | / |
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| MSDS | / | Flash Point | 222.7±25.0 °C |
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Names
| Name | chrysosplenetin |
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| Synonym | More Synonyms |
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Chrysosplenetin BiologicalActivity
| Description | Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Cytochrome P450Signaling Pathways >>Membrane Transporter/Ion Channel >>P-glycoproteinResearch Areas >>Metabolic Disease |
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| Target | CYP3A |
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| References | [1]. Ma L, et al. Chrysosplenetin inhibits artemisinin efflux in P-gp-over-expressing Caco-2 cells and reverses P-gp/MDR1 mRNA up-regulated expression induced by artemisinin in mouse small intestine. Pharm Biol. 2017 Dec;55(1):374-380. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 615.8±55.0 °C at 760 mmHg |
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| Molecular Formula | C19H18O8 |
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| Molecular Weight | 374.341 |
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| Flash Point | 222.7±25.0 °C |
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| Exact Mass | 374.100159 |
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| PSA | 107.59000 |
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| LogP | 2.26 |
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| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
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| Index of Refraction | 1.640 |
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| InChIKey | NBVTYGIYKCPHQN-UHFFFAOYSA-N |
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| SMILES | COc1cc(-c2oc3cc(OC)c(OC)c(O)c3c(=O)c2OC)ccc1O |
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| Storage condition | 2-8℃ |
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Safety Information
Synonyms
| Chrysosplenetin |
| 4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy- |
| 5,3'-Dipropyl-biphenyl-2,4'-diol |
| chrysoplenitin |
| 4',5-dihydroxy-3,6,7,3'-tetramethoxyflavone |
| 3,6,7,3'-tetra-methylquercetagetin |
| 5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-4H-chromen-4-one |
| Tetrahydrohonokiol |
| Chrysosplenetin B |
| Tetrahydrohoenokiol |
| chrysosplenol B |
| Quercetagetin 3,6,7,3'-tetramethyl ether |
| 5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-4H-chrom en-4-one |
