CAS 6601-62-3|Scrophulein
| Common Name | Scrophulein | ||
|---|---|---|---|
| CAS Number | 6601-62-3 | Molecular Weight | 314.289 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 563.6±50.0 °C at 760 mmHg |
| Molecular Formula | C17H14O6 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 211.5±23.6 °C |
| Symbol | GHS06, GHS09 | Signal Word | Danger |
Names
| Name | cirsimaritin |
|---|---|
| Synonym | More Synonyms |
Scrophulein BiologicalActivity
| Description | Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors, with antidepressant, anxiolytic and antinociceptive activities. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorSignaling Pathways >>Neuronal Signaling >>GABA ReceptorResearch Areas >>Neurological DiseaseNatural Products >>Others |
| In Vivo | Cirsimaritin significantly reduces the anxiety in mice. Cirsimaritin does not decrease by co-administration of flumazenil (2.5 mg/kg) with salvigenin, rosmanol and cirsimaritin (10 mg/kg), indicating that the high-affinity benzodiazepine binding site is not involved in the anxiolytic activity induced by these compounds[1]. |
| References | [1]. Abdelhalim A, et al. Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis. J Pharm Pharm Sci. 2015;18(4):448-59. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 563.6±50.0 °C at 760 mmHg |
| Molecular Formula | C17H14O6 |
| Molecular Weight | 314.289 |
| Flash Point | 211.5±23.6 °C |
| Exact Mass | 314.079041 |
| PSA | 89.13000 |
| LogP | 1.97 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.646 |
| InChIKey | ZIIAJIWLQUVGHB-UHFFFAOYSA-N |
| SMILES | COc1cc2oc(-c3ccc(O)cc3)cc(=O)c2c(O)c1OC |
| Storage condition | ?20°C |
Safety Information
| Symbol | GHS06, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H410 |
| Precautionary Statements | P273-P301 + P310-P501 |
| Hazard Codes | T,N |
| Risk Phrases | 25-50 |
| Safety Phrases | 45-61 |
| RIDADR | UN 2811 6.1 / PGIII |
| HS Code | 2914509090 |
Customs
| HS Code | 2914509090 |
|---|---|
| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
Articles13
More Articles| [Studies on flavonoid constituents from herbs of Artemisia ordosica II]. Zhongguo Zhong Yao Za Zhi 31(23) , 1959-61, (2006) To study the chemical constituents of herbs of Artemisia ordosica.The chemical constituents were isolated and repeatedly purified on silica gel column and the structures were elucidated by the NMR spe... | |
| [Study on chemical constituents from Incarvillea arguta and their accelerating PC-12 cell differentiation]. Zhongguo Zhong Yao Za Zhi 30(17) , 1335-8, (2005) To study chemical constituents of Incarvillea arguta and their accelerating PC-12 cell differentiation.The constituents were isolated and repeatedly purified on silica gel column chromatography, and w... | |
| [Determination of flavonoids in buds of Herba Artemisiae Scopariae by HPLC]. Zhongguo Zhong Yao Za Zhi 30(8) , 591-4, (2005) To develop a quantitative method for the determination of four flavonoids in buds of Herba Artemisiae Scopariae.The sample was extracted by ultrasonic with ethyl acetate for 30 minutes and separated o... |
Synonyms
| 5,4'-dihydroxy-6,7-dimethoxyflavone |
| 5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxychromen-4-one |
| Flavone, 4',5-dihydroxy-6,7-dimethoxy- |
| 6,7-Dimethoxyscutellarein |
| Circimaritin |
| 7-Methylcapillarisin |
| 5-Hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-4H-chromen-4-one |
| cirsimartin |
| 5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-chromen-4-one |
| Scrophulein |
| 4H-1-Benzopyran-4-one,5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy |
| Skrofulein |
| 4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy- |
| 4',5-Dihydroxy-6,7-dimethoxyflavone |
| cirsimaritin |
