Introduction：Basic information about CAS 524-15-2|gamma-Fagarine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | gamma-Fagarine |
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| CAS Number | 524-15-2 | Molecular Weight | 229.231 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 381.0±37.0 °C at 760 mmHg |
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| Molecular Formula | C13H11NO3 | Melting Point | 142° |
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| MSDS | / | Flash Point | 184.2±26.5 °C |
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Names
| Name | 4,8-Dimethoxyfuro[2,3-b]quinoline |
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| Synonym | More Synonyms |
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gamma-Fagarine BiologicalActivity
| Description | γ-Fagarine is a furoquinoline alkaloid naturally occurring in Rutae Herba. γ-Fagarine has strong anti-HCV activities with IC50 of 20.4 μg/mL and is also a sister chromatid exchanges (SCEs) inducer[1][2]. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>HCVResearch Areas >>Infection |
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| Target | IC50: 20.4 μg/mL (HCV)[1] |
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| References | [1]. Tutik Sri Wahyuni, et al. Inhibition of Hepatitis C Virus Replication by Chalepin and Pseudane IX Isolated From Ruta Angustifolia Leaves. Fitoterapia. 2014 Dec;99:276-83. [2]. O Schimmer, et al. The SCE-inducing Potency of the Furoquinoline Alkaloid, Gamma-Fagarine, and a Gamma-Fagarine-Containing Tincture From Rutae Herba, in Cultured Human Lymphocytes. Mutagenesis. 1989 Nov;4(6):467-70. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 381.0±37.0 °C at 760 mmHg |
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| Melting Point | 142° |
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| Molecular Formula | C13H11NO3 |
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| Molecular Weight | 229.231 |
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| Flash Point | 184.2±26.5 °C |
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| Exact Mass | 229.073898 |
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| PSA | 44.49000 |
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| LogP | 2.70 |
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| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
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| Index of Refraction | 1.643 |
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| InChIKey | KFBCTNNQFGONHB-UHFFFAOYSA-N |
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| SMILES | COc1c2ccoc2nc2c(OC)cccc12 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- LV2708200
- CHEMICAL NAME :
- Furo(2,3-b)quinoline, 4,8-dimethoxy-
- CAS REGISTRY NUMBER :
- 524-15-2
- BEILSTEIN REFERENCE NO. :
- 0212820
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C13-H11-N-O3
- MOLECULAR WEIGHT :
- 229.25
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 1 ug/plate
- REFERENCE :
- MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,349,1988
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2934999090 |
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Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 8-Methoxydictamine |
| 8-Methoxydictamnine |
| 4,8-Dimethoxyfuro[2,3-b]quinoline |
| Fagarine |
| Furo[2,3-b]quinoline, 4,8-dimethoxy- |
| g-fagarine |
| γ-Fagarine |
