CAS 1008119-83-2|JM6
Introduction：Basic information about CAS 1008119-83-2|JM6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | JM6 | ||
|---|---|---|---|
| CAS Number | 1008119-83-2 | Molecular Weight | 518.60600 |
| Density | / | Boiling Point | / |
| Molecular Formula | C23H26N4O6S2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-5-(1-piperidinylmethyl)-1,3-th iazol-2-yl]benzenesulfonamide |
|---|---|
| Synonym | More Synonyms |
JM6 BiologicalActivity
| Description | JM6 is a weak kynurenine 3-monooxygenase (KMO) inhibitor with an IC50 of 19.85 μM for mouse KMO. JM6 can be used for Alzheimer's diseases research[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
| Target | IC50: 19.85 μM (kynurenine 3-monooxygenase)[1] |
| References | [1]. Maria G Beconi, et al. Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048. Drug Metab Dispos. 2012 Dec;40(12):2297-306. |
Chemical & Physical Properties
| Molecular Formula | C23H26N4O6S2 |
|---|---|
| Molecular Weight | 518.60600 |
| Exact Mass | 518.12900 |
| PSA | 163.20000 |
| LogP | 6.13710 |
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| RIDADR | UN 2811 6.1 / PGIII |
Articles1
More Articles| Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model. Neuropharmacology 102 , 80-91, (2016) Recent studies have highlighted the involvement of the kynurenine pathway in the pathology of neurodegenerative diseases, but the role of this system in neuropathic pain requires further extensive res... |
Synonyms
| 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-5-(1-piperidinylmethyl)-2-thiazolyl]-benzenesulfonamide |
| JM6 |
