Introduction：Basic information about CAS 865783-99-9|Briciclib, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Briciclib |
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| CAS Number | 865783-99-9 | Molecular Weight | 474.419 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 762.6±70.0 °C at 760 mmHg |
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| Molecular Formula | C19H23O10PS | Melting Point | / |
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| MSDS | / | Flash Point | 415.0±35.7 °C |
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Names
| Name | 2-Methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methy l)phenyl dihydrogen phosphate |
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| Synonym | More Synonyms |
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Briciclib BiologicalActivity
| Description | Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers. |
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| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>Eukaryotic Initiation Factor (eIF)Research Areas >>Cancer |
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| Target | eIF4E[1] |
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| In Vitro | Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours[1]. |
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| References | [1]. Neel Jasani, et al. Abstract 1649: Potent anticancer activity of an orally bioavailable small molecule, ON 013100, and its water soluble derivative, briciclib, a clinical-stage eIF4E-targeted agent. Cancer Research. August 2015, Volume 75, Issue 15. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 762.6±70.0 °C at 760 mmHg |
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| Molecular Formula | C19H23O10PS |
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| Molecular Weight | 474.419 |
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| Flash Point | 415.0±35.7 °C |
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| Exact Mass | 474.074951 |
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| PSA | 156.01000 |
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| LogP | 0.89 |
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| Appearance of Characters | white solid |
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| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
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| Index of Refraction | 1.578 |
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| InChIKey | LXENKEWVEVKKGV-BQYQJAHWSA-N |
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| SMILES | COc1cc(OC)c(C=CS(=O)(=O)Cc2ccc(OC)c(OP(=O)(O)O)c2)c(OC)c1 |
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| Storage condition | -20℃ |
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Synonyms
| 2-Methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methyl)phenyl dihydrogen phosphate |
| ON 014185 |
| Phenol, 2-methoxy-5-[[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]-, dihydrogen phosphate |
| Briciclib |
| Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate) |
