CAS 130804-35-2|lecimibide

Introduction：Basic information about CAS 130804-35-2|lecimibide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. lecimibide BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	lecimibide
CAS Number	130804-35-2	Molecular Weight	590.76900
Density	1.21g/cm3	Boiling Point	/
Molecular Formula	C₃₄H₄₀F₂N₄OS	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	3-(2,4-difluorophenyl)-1-[5-[(4,5-diphenyl-1H-imidazol-2-yl)sulfanyl]pentyl]-1-heptylurea
Synonym	More Synonyms

lecimibide BiologicalActivity

Description	Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research[1][2].
Related Catalog	Research Areas >>Metabolic Disease
In Vitro	Lecimibide (DuP 128)(10 μM, 24 h)可以抑制 HepG2 细胞 85% 的细胞酯化反应[1]。
In Vivo	Lecimibide (DuP 128)(i.v., 2.2 mg/kg/day) 在饲养高脂肪和胆固醇的猪中，显著降低了总血浆甘油三酯和极低密度脂蛋白(VLDL)甘油三酯浓度，分别降低了 36% 和 31%。而对总胆固醇、VLDL 胆固醇、LDL 胆固醇、HDL 胆固醇或 LDL apoB 浓度没有显著影响[2]。
References	[1]. L J Wilcox, et al. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res. 2001 May;42(5):725-34. [2]. J R Burnett, et al. Inhibition of cholesterol esterification by DuP 128 decreases hepatic apolipoprotein B secretion in vivo: effect of dietary fat and cholesterol. Biochim Biophys Acta. 1998 Jul 31;1393(1):63-79.

Chemical & Physical Properties

Density	1.21g/cm3
Molecular Formula	C₃₄H₄₀F₂N₄OS
Molecular Weight	590.76900
Exact Mass	590.28900
PSA	89.81000
LogP	9.80240
Index of Refraction	1.613
InChIKey	TVXOXGBTADZYCZ-UHFFFAOYSA-N
SMILES	CCCCCCCN(CCCCCSc1nc(-c2ccccc2)c(-c2ccccc2)[nH]1)C(=O)Nc1ccc(F)cc1F

Synonyms

N'-(2,4-difluorophenyl)-N-[5-(4,5-diphenyl-1H-imidazol-2-ylthio)pentyl]-N-heptylurea

urea,n'-(2,4-difluorophenyl)-n-[5-[(4,5-diphenyl-1h-imidazol-2-yl)thio]pentyl]-n-heptyl

Lecimibide

Lecimibide (USAN)

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