CAS 56725-99-6|Icariside I

Introduction：Basic information about CAS 56725-99-6|Icariside I, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Icariside I BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Synonyms

Common Name	Icariside I
CAS Number	56725-99-6	Molecular Weight	530.521
Density	1.5±0.1 g/cm3	Boiling Point	801.3±65.0 °C at 760 mmHg
Molecular Formula	C₂₇H₃₀O₁₁	Melting Point	/
MSDS	/	Flash Point	267.8±27.8 °C

Names

Name	3,5-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
Synonym	More Synonyms

Icariside I BiologicalActivity

Description	Icariside I is a metabolite of Icarlin, which could regulate bone remodeling and is recognized as an effective agent for the treatment of osteoporosis.
Related Catalog	Signaling Pathways >>Others >>OthersNatural Products >>FlavonoidsResearch Areas >>Others
References	[1]. Cheng T, et al. Metabolism profiles of icariin in rats using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry and in vitro enzymatic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 15;1033-1034:353-360. [2]. Ming LG, et al. Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling. J Cell Physiol. 2013 Mar;228(3):513-21.

Description

Icariside I is a metabolite of Icarlin, which could regulate bone remodeling and is recognized as an effective agent for the treatment of osteoporosis.

Related Catalog

Signaling Pathways >>Others >>OthersNatural Products >>FlavonoidsResearch Areas >>Others

References

[1]. Cheng T, et al. Metabolism profiles of icariin in rats using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry and in vitro enzymatic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 15;1033-1034:353-360.

[2]. Ming LG, et al. Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling. J Cell Physiol. 2013 Mar;228(3):513-21.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	801.3±65.0 °C at 760 mmHg
Molecular Formula	C₂₇H₃₀O₁₁
Molecular Weight	530.521
Flash Point	267.8±27.8 °C
Exact Mass	530.178833
PSA	179.28000
LogP	2.60
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.664
InChIKey	IYCPMVXIUPYNHI-WPKKLUCLSA-N
SMILES	COc1ccc(-c2oc3c(CC=C(C)C)c(OC4OC(CO)C(O)C(O)C4O)cc(O)c3c(=O)c2O)cc1
Storage condition	2-8C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ2984200

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 3,5-dihydroxy-7-(beta-D-glucopyranosyloxy)-2-(4-metho xyphenyl)-8- (3-methyl-2-butenyl)-

CAS REGISTRY NUMBER :: 56725-99-6

BEILSTEIN REFERENCE NO. :: 0072036

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C27-H30-O11

MOLECULAR WEIGHT :: 530.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Mammal - species unspecified Leukocyte

DOSE/DURATION :: 625 ug/L

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 53,175,1990

Synonyms

Lcariside I

icariside II

Baohuoside-1

icarisid I

3,5-Dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4-oxo-4H-chromen-7-yl β-D-glucopyranoside

4H-1-Benzopyran-4-one, 7-(β-D-glucopyranosyloxy)-3,5-dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-

Icariside I

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