Introduction：Basic information about CAS 69542-93-4|Pivagabine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pivagabine |
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| CAS Number | 69542-93-4 | Molecular Weight | 187.23600 |
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| Density | 1.053g/cm3 | Boiling Point | 397ºC at 760 mmHg |
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| Molecular Formula | C9H17NO3 | Melting Point | / |
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| MSDS | / | Flash Point | 193.9ºC |
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Names
| Name | 4-Pivalamidobutanoic acid |
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| Synonym | More Synonyms |
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Pivagabine BiologicalActivity
| Description | Pivagabine (CXB 722), a psychoactive drug, is a hydrophobic 4-aminobutyric acid derivative with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| In Vivo | Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions[2]. Animal Model: Adult male Sprague-Dawley CD rats (200-250 g)[2] Dosage: 200 mg/kg Administration: i.p.; twice a day for 4 days and 1 hour before killing on the 5th day Result: Prevented the effects of foot-shock stress on CRF concentration in both brain regions. Reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex. |
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| References | [1]. Esposito G, et al. Pivagabine: a novel psychoactive drug. Arzneimittelforschung. 1997 Nov;47(11A):1306-9. [2]. Serra M, et al. Antagonism by pivagabine of stress-induced changes in GABAA receptor function and corticotropin-releasing factor concentrations in rat brain. Psychoneuroendocrinology. 1999 Apr;24(3):269-84. |
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Chemical & Physical Properties
| Density | 1.053g/cm3 |
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| Boiling Point | 397ºC at 760 mmHg |
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| Molecular Formula | C9H17NO3 |
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| Molecular Weight | 187.23600 |
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| Flash Point | 193.9ºC |
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| Exact Mass | 187.12100 |
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| PSA | 69.89000 |
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| LogP | 1.85380 |
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| Index of Refraction | 1.462 |
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| InChIKey | SRPNQDXRVRCTNK-UHFFFAOYSA-N |
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| SMILES | CC(C)(C)C(=O)NCCCC(=O)O |
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| Storage condition | 2-8°C |
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Synonyms
| 4-(2,2-dimethylpropanoylamino)butanoic acid |
