Introduction：Basic information about CAS 1012343-93-9|IRAK inhibitor 3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | IRAK inhibitor 3 |
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| CAS Number | 1012343-93-9 | Molecular Weight | 439.48800 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C21H21N5O4S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-[[[3-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]methyl]benzenesulfonamide |
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| Synonym | More Synonyms |
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IRAK inhibitor 3 BiologicalActivity
| Description | IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>IRAKSignaling Pathways >>Protein Tyrosine Kinase/RTK >>IRAKResearch Areas >>Inflammation/Immunology |
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| Target | IRAK[1] |
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| In Vitro | IRAK inhibitor 3 is an IRAK modulator, which can be used for treating an inflammatory condition, cell proliferative disorder, immune disorder[1]. |
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| Kinase Assay | 5 μL of a solution of IRAK inhibitor 3 at a concentration of 50 μM or less in 1% (v/v) DMSO is added to the wells of a 96-well area Black Polystyrene plates. The final concentrations in the reaction well are 10 μM ATP, 0.5 μM IRAK4 CH373, 1.6 μM IRAKI peptide, 1 mM MgCl2, 2 mM DTT, 5 mM MnCl2, 0.01 % BSA, and 0.01 % Tween-20. The volume of the reaction is 45 μL. The reaction mixture is incubated at room temperature for 30 minutes and stopped with the addition of 5 μL of 100 mM EDTA[1]. |
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| References | [1]. Thomas Durand-Reville, et al. Irak modulators for treating an inflammatory condition, cell proliferative disorder, immune disorder. WO 2008030579 A2. |
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Chemical & Physical Properties
| Molecular Formula | C21H21N5O4S |
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| Molecular Weight | 439.48800 |
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| Exact Mass | 439.13100 |
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| PSA | 132.45000 |
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| LogP | 3.87600 |
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| InChIKey | UPFVAHVWLNBVSG-UHFFFAOYSA-N |
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| SMILES | COc1ccc(-c2cnc3ccc(NCc4ccc(S(N)(=O)=O)cc4)nn23)cc1OC |
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| Storage condition | 2-8℃ |
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Synonyms
| IRAK inhibitor 3 |
| 4-((3-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-ylamino)methyl)-benzenesulfonamide |
| CS-0605 |
