Introduction：Basic information about CAS 1093070-16-6|GRL 0617, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | GRL 0617 |
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| CAS Number | 1093070-16-6 | Molecular Weight | 304.38600 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C20H20N2O | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 5-amino-2-methyl-N-(2-naphthalen-1-ylethyl)benzamide |
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| Synonym | More Synonyms |
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GRL 0617 BiologicalActivity
| Description | GRL0617 is a potent, selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLpro)/deubiquitinase, with an IC50 of 0.6 μM, and with a Ki of 0.49 μM[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>DeubiquitinaseSignaling Pathways >>Anti-infection >>SARS-CoV |
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| Target | IC50: 0.6 μM (SARS-CoV PLpro)[1] |
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| References | [1]. Ratia K, et al. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24. |
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Chemical & Physical Properties
| Molecular Formula | C20H20N2O |
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| Molecular Weight | 304.38600 |
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| Exact Mass | 304.15800 |
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| PSA | 58.61000 |
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| LogP | 4.85890 |
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| InChIKey | UVERBUNNCOKGNZ-CQSZACIVSA-N |
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| SMILES | Cc1ccc(N)cc1C(=O)NC(C)c1cccc2ccccc12 |
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Synonyms
| I06-1403 |
| 5-azanyl-2-methyl-N-(2-naphthalen-1-ylethyl)benzamide |
| 5-amino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide |
| 5-amino-2-methyl-N-[2-(1-naphthalenyl)ethyl]benzamide |
