Introduction：Basic information about CAS 466-07-9|Neriifolin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Neriifolin |
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| CAS Number | 466-07-9 | Molecular Weight | 534.68100 |
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| Density | 1.274g/cm3 | Boiling Point | 700.079ºC at 760 mmHg |
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| Molecular Formula | C30H46O8 | Melting Point | 218-225ºC |
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| MSDS | / | Flash Point | 224.862ºC |
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Names
| Name | neriifolin |
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| Synonym | More Synonyms |
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Neriifolin BiologicalActivity
| Description | Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[1][2. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>Inflammation/Immunology |
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| In Vitro | Neriifolin (0.1μg/mL; 48 hours) induces apoptosis in HepG2 cells. Neriifolin (0-8 μg/mL; 72 hours) reduces viability of HepG2 cells. Neriifolin also induces S and G2/M phase arrests of the cell cycle and stimulates apoptosis of HepG2 cells. Stimulation of HepG2 cells with Neriifolin induced activation of caspase-3, -8, and -9, and up-regulated expression of Fas and FasL proteins[1]. |
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| References | [1]. Keller CW, et al. ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation. Proc Natl Acad Sci U S A. 2017;114(52):E11228-E11237. [2]. Zhao Q, et al. Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Fitoterapia. 2011;82(5):735-741. |
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Chemical & Physical Properties
| Density | 1.274g/cm3 |
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| Boiling Point | 700.079ºC at 760 mmHg |
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| Melting Point | 218-225ºC |
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| Molecular Formula | C30H46O8 |
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| Molecular Weight | 534.68100 |
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| Flash Point | 224.862ºC |
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| Exact Mass | 534.31900 |
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| PSA | 114.68000 |
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| LogP | 3.11020 |
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| Vapour Pressure | 0mmHg at 25°C |
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| Index of Refraction | 1.581 |
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| InChIKey | VPUNMTHWNSJUOG-BAOINKAISA-N |
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| SMILES | COC1C(O)C(C)OC(OC2CCC3(C)C(CCC4C3CCC3(C)C(C5=CC(=O)OC5)CCC43O)C2)C1O |
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Safety Information
| Hazard Codes | T+ |
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| Risk Phrases | 26/27/28 |
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| Safety Phrases | 22-36/37/39-45 |
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| RIDADR | UN 2811 6.1/PG 1 |
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| WGK Germany | 3 |
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| RTECS | FH4906100 |
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Synonyms
| NERIIFOLIN |
| 17Beta-Neriifolin |
| xy)-14-hydroxy |
| digitoxigenin+thevetose |
