CAS 67269-08-3|(Deamino-Pen1,Tyr(Me)2, Arg8)-Vasopressin trifluoroacetate salt
| Common Name | (Deamino-Pen1,Tyr(Me)2, Arg8)-Vasopressin trifluoroacetate salt | ||
|---|---|---|---|
| CAS Number | 67269-08-3 | Molecular Weight | 1111.30 |
| Density | 1.49g/cm3 | Boiling Point | / |
| Molecular Formula | C49H70N14O12S2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 1-Deaminopenicillamine-2-(O-methyl-tyr)-argipressin |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | Dp[Tyr(methyl)2,Arg8]-Vasopressin is a non-selective peptide arginine vasopressin Vlb receptor antagonist[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Vasopressin ReceptorResearch Areas >>Metabolic Disease |
| References | [1]. Kamal A. Al-Barazanji. Use of vasopressin receptor antagonist for regulation of acth release. WO1997035602A1. |
Chemical & Physical Properties
| Density | 1.49g/cm3 |
|---|---|
| Molecular Formula | C49H70N14O12S2 |
| Molecular Weight | 1111.30 |
| Exact Mass | 1110.47000 |
| PSA | 475.01000 |
| LogP | 2.60510 |
| Index of Refraction | 1.684 |
| InChIKey | HNOGCDKPALYUIG-UHFFFAOYSA-N |
| SMILES | COc1ccc(CC2NC(=O)CC(C)(C)SSCC(C(=O)N3CCCC3C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(Cc3ccccc3)NC2=O)cc1 |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H332 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| RIDADR | NONH for all modes of transport |
Articles30
More Articles| Arginine vasopressin enhances pHi regulation in the presence of HCO3- by stimulating three acid-base transport systems. Nature 337(6208) , 648-51, (1989) Growth factors raise intracellular pH (pHi) by stimulating Na+/H+ exchange in the absence of HCO3-. In mutant cells that lack the Na+/H+ exchange activity, this alkalinization does not occur, and the ... | |
| Arginine vasopressin in advanced vasodilatory shock: a prospective, randomized, controlled study. Circulation 107(18) , 2313-9, (2003) Vasodilatory shock is a potentially lethal complication of severe disease in critically ill patients. Currently, catecholamines are the most widely used vasopressor agents to support blood pressure, b... | |
| Role of arginine vasopressin V1 and V2 receptors for brain damage after transient focal cerebral ischemia. J. Cereb. Blood Flow Metab. 25(8) , 1012-9, (2005) Brain edema formation is one of the most important mechanisms responsible for brain damage after ischemic stroke. Despite considerable efforts, no specific therapy is available yet. Arginine vasopress... |
Synonyms
| vasopressin deamino-Pen1,O-Me-tyrosine-2,arginine-8 |
| (DEAMINO-PEN1,TYR(ME)2,ARG8)-VASOPRESSIN |
| 3-mercapto-3-methyl-butyryl-tyr(me)-phe-gln-asn-cys-pro-arg-gly-nh2 |
| [Pmp1,Tyr(OMe)2,Arg8] Vasopressin |
