Introduction：Basic information about CAS 81039-85-2|[DPro4,DTrp7,9] Substance P: 4-11, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | [DPro4,DTrp7,9] Substance P: 4-11 |
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| CAS Number | 81039-85-2 | Molecular Weight | 1134.35000 |
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| Density | 1.31 g/cm3 | Boiling Point | 1622.3ºC at 760 mmHg |
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| Molecular Formula | C57H75N13O10S | Melting Point | / |
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| MSDS | / | Flash Point | 935ºC |
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Names
| Name | d-pro-gln-gln-d-trp-phe-d-trp-leu-met-nh2 |
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| Synonym | More Synonyms |
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[DPro4,DTrp7,9] Substance P: 4-11 BiologicalActivity
| Description | [D-Pro4,D-Trp7,9] Substance P (4-11) is a potent antagonist of Substance P (HY-P0201). [D-Pro4,D-Trp7,9] Substance P (4-11) decreases plasma aldosterone (ALDO) concentration[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| In Vivo | [D-Pro4,D-Trp7,9] Substance P (4-11) inhibits the hypotensive effect of Substance P in anesthetized rats, the vasodilator effect in the rabbit perfused heart, relaxation induced by Substance P in dog carotid arteries contracted with noradrenaline, and stimulatory actions of Substance P in the guinea pig ileum and the guinea pig trachea[1]. [D-Pro4,D-Trp7,9] Substance P (4-11) (0.3 nM/K/min; i.p. for 7 days) significantly decreases plasma aldosterone (ALDO) concentration and causes atrophy of adrenal zona glomerulosa (ZG) and its parenchymal cells[2]. |
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| References | [1]. Mizrahi J, et al. Substance P antagonists active in vitro and in vivo. Eur J Pharmacol. 1982 Aug 13;82(1-2):101-5. [2]. Mazzocchi G, et al. Evidence that endogenous substance-P (SP) is involved in the maintenance of the growth and steroidogenic capacity of rat adrenal zona glomerulosa. Neuropeptides. 1995 Jul;29(1):53-8. |
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Chemical & Physical Properties
| Density | 1.31 g/cm3 |
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| Boiling Point | 1622.3ºC at 760 mmHg |
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| Molecular Formula | C57H75N13O10S |
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| Molecular Weight | 1134.35000 |
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| Flash Point | 935ºC |
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| Exact Mass | 1133.55000 |
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| PSA | 401.88000 |
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| LogP | 5.80420 |
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| Index of Refraction | 1.627 |
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| InChIKey | HYFDLZDVAMNRAV-UYPBBLEUSA-N |
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| SMILES | CSCCC(NC(=O)C(CC(C)C)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1)C(N)=O |
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Synonyms
| H-D-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Met-NH2 |
| [DPro4,DTrp7,9] Substance P: 4-11 |
