Introduction：Basic information about CAS 80434-86-2|(D-Pro2,D-Trp7·9)-Substance P acetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (D-Pro2,D-Trp7·9)-Substance P acetate salt |
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| CAS Number | 80434-86-2 | Molecular Weight | 1515.82000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C74H106N20O13S | Melting Point | / |
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| MSDS | USA | Flash Point | / |
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Names
| Name | [d-pro2, d-trp7,9]-substance p |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | [D-Pro2,D-Trp7,9] Substance P, a Substance P (HY-P0201) analogue, is a weak agonist and a potent, specific, competitive Substance P antagonist[1][2]. |
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| Related Catalog | Research Areas >>Inflammation/Immunology |
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| In Vitro | [D-Pro2,D-Trp7,9] Substance P decreases proliferation only in a few cell lines, and only in the highest concentration (100 µM). [D-Pro2,D-Trp7,9] Substance P displays a significantly weaker antiproliferative action than Aprepitant (HY-10052) on cancer or normal cell lines[3]. |
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| In Vivo | [D-Pro2,D-Trp7,9] Substance P (0-30 nmol, Intravitreal injection) greatly reduces not only the effects of exogenous Substance P (HY-P0201) but also the inflammatory response to trauma to the eye[1]. [D-Pro2,D-Trp7,9] Substance P specifically antagonizes the contractile effects of Substance P on the guinea-pig isolated taenia coli[2]. Animal Model: Adult pigmented rabbits (1.5-3 kg)[1] Dosage: 0.03, 0.3, 3, and 30 nmol Administration: Intravitreal injection or topical application onto the eye, 60 μL Result: Reduced the inflammatory response to Substance P. Dependently reduced the inflammatory response to infrared irradiation. In itself, intravitreal injection of low doses of [D-Pro2, D-Trp7'9]SP had no effects on the eye. |
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| References | [1]. Holmdahl G, et al. A substance P antagonist, [D-Pro2, D-Trp7,9]SP, inhibits inflammatory responses in the rabbit eye. Science. 1981 Nov 27;214(4524):1029-31. [2]. Håkanson R, et al. The mechanism of action of a substance P antagonist (D-Pro2, D-Trp7,9)-SP. Br J Pharmacol. 1982 Dec;77(4):697-700. [3]. Matalińska J, et al. Antiproliferative effects of [D-Pro2, D-Trp7,9]-Substance P and aprepitant on several cancer cell lines and their selectivity in comparison to normal cells. Folia Neuropathol. 2020;58(3):237-244. English. |
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Chemical & Physical Properties
| Molecular Formula | C74H106N20O13S |
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| Molecular Weight | 1515.82000 |
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| Exact Mass | 1514.80000 |
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| PSA | 573.51000 |
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| LogP | 6.76800 |
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| InChIKey | ARZXOJGZBACSSO-OLMCGDJQSA-N |
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| SMILES | CSCCC(NC(=O)C(CC(C)C)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(N)CCCN=C(N)N)C(N)=O |
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Synonyms
| 2-Pro-7,9-Trp-substance p |
| 2-Pro-7,9-Trp-sp |
| Pttsp |
| Pt-sp |
| <D-Pro2,D-Trp7,9>-SP |
| dt79 |
| [DPro2,DTrp7,9] Substance P |
