CAS 72450-62-5|4-BROMO-BENZENESULFONIC ACID
| Common Name | 4-BROMO-BENZENESULFONIC ACID | ||
|---|---|---|---|
| CAS Number | 72450-62-5 | Molecular Weight | 165.21 |
| Density | 1.39g/cm3 | Boiling Point | / |
| Molecular Formula | C5H11NO3S | Melting Point | > 300 °C |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | piperidine-4-sulfonic acid |
|---|---|
| Synonym | More Synonyms |
4-BROMO-BENZENESULFONIC ACID BiologicalActivity
| Description | Piperidine-4-sulfonic acid is a potent GABA agonist with an IC50 of 0.034 μM for the inhibition of the binding of H-GABA[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersSignaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor |
| Target | IC50: 0.034 μM (the binding of H-GABA)[1] |
| References | [1]. POVL KROGSGAARD-LARSEN, et al. Pharmacological Studies of Interactions Between Benzodiazepines and GABA Receptors. Brain Research Rullrrin. 1980, 5(2):867-872. [2]. Krogsgaard-Larsen P, Arnt J. Pharmacological studies of interactions between benzodiazepines and GABA receptors. Brain Research Bulletin, 1980, 5: 867-872. |
Chemical & Physical Properties
| Density | 1.39g/cm3 |
|---|---|
| Melting Point | > 300 °C |
| Molecular Formula | C5H11NO3S |
| Molecular Weight | 165.21 |
| Exact Mass | 165.04600 |
| PSA | 74.78000 |
| LogP | 1.03580 |
| Index of Refraction | 1.537 |
| InChIKey | UGBJGGRINDTHIH-UHFFFAOYSA-N |
| SMILES | O=S(=O)(O)C1CCNCC1 |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| HS Code | 2933399090 |
Customs
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles28
More Articles| Modulation of [3H]diazepam binding in rat cortical membranes by GABAA agonists. J. Neurochem. 44(4) , 1162-7, (1985) GABAA receptor agonists modulate [3H]diazepam binding in rat cortical membranes with different efficacies. At 23 degrees C, the relative potencies for enhancement of [3H]diazepam binding by agonists p... | |
| Effects of GABA(A) receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions. Br. J. Pharmacol. 133(4) , 539-49, (2001) Based on an unexpected high maximum response to piperidine-4-sulphonic acid (P4S) at human alpha1alpha6beta2gamma2 GABA(A) receptors expressed in Xenopus oocytes attempts to correlate this finding wit... | |
| Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: a kinetic analysis. Biochem. Pharmacol. 71(10) , 1510-9, (2006) The use of the antiepileptic drug, 4-aminobutyrate transaminase (GABA-T) inhibitor vigabatrin (VIGA), has been recently cautioned because it is associated to irreversible field defects from damage of ... |
Synonyms
| C5H11NO3S |
| P4S |
| Lopac-P-9159 |
| 4-Piperidinesulfonic acid |
| Piperidine-4-sulphonic acid |
