Introduction：Basic information about CAS 756525-99-2|Mal-amido-PEG4-NHS ester, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Mal-amido-PEG4-NHS ester |
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| CAS Number | 756525-99-2 | Molecular Weight | 513.49500 |
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| Density | 1.36±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C22H31N3O11 | Melting Point | / |
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| MSDS | USA | Flash Point | / |
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Names
| Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
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| Synonym | More Synonyms |
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Mal-amido-PEG4-NHS ester BiologicalActivity
| Description | Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs Alkyl/ether |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
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Chemical & Physical Properties
| Density | 1.36±0.1 g/cm3 |
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| Molecular Formula | C22H31N3O11 |
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| Molecular Weight | 513.49500 |
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| Exact Mass | 513.19600 |
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| PSA | 170.57000 |
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| InChIKey | XSRYGQJQNPJNKZ-UHFFFAOYSA-N |
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| SMILES | O=C(CCN1C(=O)C=CC1=O)NCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Synonyms
| monodisperse Mal-PEG4-NHS-ester |
| AmbotzPEG1575 |
| Maleimide-PEG4-NHS Ester |
