Introduction：Basic information about CAS 2345-17-7|Irisolidone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Irisolidone |
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| CAS Number | 2345-17-7 | Molecular Weight | 314.28900 |
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| Density | 1.402g/cm3 | Boiling Point | 565.5ºC at 760mmHg |
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| Molecular Formula | C17H14O6 | Melting Point | 192 ºC (methanol ) |
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| MSDS | / | Flash Point | 212.3ºC |
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Names
| Name | 5,7-dihydroxy-6-methoxy-3-(4-methoxyphenyl)chromen-4-one |
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| Synonym | More Synonyms |
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Irisolidone BiologicalActivity
| Description | Irisolidone is a major isoflavone found in Pueraria lobata flowers. Irisolidone exhibits potent hepatoprotective activity. Irisolidone shows the high efficacy for volume-regulated anion channels (VRAC) blockade[1][2][3]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Membrane Transporter/Ion Channel >>Chloride ChannelResearch Areas >>Neurological Disease |
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| In Vitro | Irisolidone shows the high efficacy for Volume-regulated anion channels (VRAC) blockade with an IC50 of 9.8 μM in HEK293 cells[3]. Irisolidone can inhibit endothelial cell proliferation[3]. |
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| References | [1]. Kim SY, et al. Irisolidone, an isoflavone metabolite, represses JC virus gene expression via inhibition of Sp1 binding in human glial cells. Biochem Biophys Res Commun. 2006 May 26;344(1):3-8. [2]. Zhang G, et al. Pharmacokinetics of irisolidone and its main metabolites in rat plasma determined by ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Nov 15;1005:23-9. [3]. Xue Y, et al. Natural and synthetic flavonoids, novel blockers of the volume-regulated anion channels, inhibit endothelial cell proliferation. Pflugers Arch. 2018 Oct;470(10):1473-1483. |
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Chemical & Physical Properties
| Density | 1.402g/cm3 |
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| Boiling Point | 565.5ºC at 760mmHg |
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| Melting Point | 192 ºC (methanol ) |
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| Molecular Formula | C17H14O6 |
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| Molecular Weight | 314.28900 |
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| Flash Point | 212.3ºC |
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| Exact Mass | 314.07900 |
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| PSA | 89.13000 |
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| LogP | 2.88840 |
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| Vapour Pressure | 2.15E-13mmHg at 25°C |
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| Index of Refraction | 1.645 |
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| InChIKey | VOOFPOMXNLNEOF-UHFFFAOYSA-N |
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| SMILES | COc1ccc(-c2coc3cc(O)c(OC)c(O)c3c2=O)cc1 |
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| Storage condition | 2-8℃ |
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| Water Solubility | Practically insoluble (0.05 g/L) (25 ºC) |
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Safety Information
Customs
| HS Code | 2914509090 |
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| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| Irisolidone |
| 4',6-dimethoxy-5,7-dihydroxyisoflavone |
| 5,7-dihydroxy-6,4'-dimethoxyisoflavone |
| 4'-O-Methyltectorigenin |
| 4'-methoxytectorigenin |
