CAS 66778-17-4|Esculin sesquihydrate

Introduction：Basic information about CAS 66778-17-4|Esculin sesquihydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Esculin sesquihydrate BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Esculin sesquihydrate
CAS Number	66778-17-4	Molecular Weight	367.31
Density	0.791 g/mL at 20 °C	Boiling Point	/
Molecular Formula	C₁₅H₁₆O_9.3/₂H₂O	Melting Point	203-205 °C
MSDS	/	Flash Point	/

Names

Name	Esculin Sesquihydrate
Synonym	More Synonyms

Esculin sesquihydrate BiologicalActivity

Description	Esculin sesquihydrate, a fluorescent coumarin glucoside, is an active ingredient of ash bark. Esculin sesquihydrate ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti?oxidative stress and anti?inflammatory effects, via the MAPK signaling pathway[1][2].
Related Catalog	Research Areas >>CancerSignaling Pathways >>MAPK/ERK Pathway >>p38 MAPK
References	[1]. Knox K, et al. The Coumarin Glucoside, Esculin, Reveals Rapid Changes in Phloem-Transport Velocity in Response to Environmental Cues. Plant Physiol. 2018 Oct;178(2):795-807. [2]. Song Y, et al. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy and induces anti-oxidative stress and anti-inflammatory effects via the MAPK pathway. Mol Med Rep. 2018 May;17(5):7395-7402.

Description

Esculin sesquihydrate, a fluorescent coumarin glucoside, is an active ingredient of ash bark. Esculin sesquihydrate ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti?oxidative stress and anti?inflammatory effects, via the MAPK signaling pathway[1][2].

Related Catalog

Research Areas >>CancerSignaling Pathways >>MAPK/ERK Pathway >>p38 MAPK

References

[1]. Knox K, et al. The Coumarin Glucoside, Esculin, Reveals Rapid Changes in Phloem-Transport Velocity in Response to Environmental Cues. Plant Physiol. 2018 Oct;178(2):795-807.

[2]. Song Y, et al. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy and induces anti-oxidative stress and anti-inflammatory effects via the MAPK pathway. Mol Med Rep. 2018 May;17(5):7395-7402.

Chemical & Physical Properties

Density	0.791 g/mL at 20 °C
Melting Point	203-205 °C
Molecular Formula	C₁₅H₁₆O_9.3/₂H₂O
Molecular Weight	367.31
Exact Mass	358.089996
PSA	159.05000
InChIKey	CQYPGSKIFJFVDQ-QWFKVUSTSA-N
SMILES	O.O=c1ccc2cc(OC3OC(CO)C(O)C(O)C3O)c(O)cc2o1

Safety Information

Hazard Codes	F;C
Risk Phrases	11-20/21/22-34-68/20/21/22-36/37/38
Safety Phrases	26-36/37/39-45-36/37
RIDADR	UN 2924 3/PG 2
WGK Germany	3.0

Synonyms

7-Hydroxy-2-oxo-2H-chromen-6-yl β-D-glucopyranoside hydrate (1:1)

MFCD00149492

2H-1-Benzopyran-2-one, 6-(β-D-glucopyranosyloxy)-7-hydroxy-, hydrate (1:1)

EINECS 208-517-5

7-hydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one,hydrate

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