CAS 108885-69-4|Taccalonolide B
Introduction：Basic information about CAS 108885-69-4|Taccalonolide B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Taccalonolide B | ||
|---|---|---|---|
| CAS Number | 108885-69-4 | Molecular Weight | 660.705 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 775.9±60.0 °C at 760 mmHg |
| Molecular Formula | C34H44O13 | Melting Point | / |
| MSDS | / | Flash Point | 242.4±26.4 °C |
Names
| Name | taccalonolide B |
|---|---|
| Synonym | More Synonyms |
Taccalonolide B BiologicalActivity
| Description | Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM[1][2]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Microtubule/TubulinSignaling Pathways >>Cytoskeleton >>Microtubule/Tubulin |
| Target | microtubule[2] |
| References | [1]. LiangChen Zhong, et al. Steroidal bitter principles from tacca plantaginea structures of taccalonolide A and B. Tetrahedron Letters. 1987, 28(15): 1673-1675. [2]. Risinger AL, et al. The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res. 2008 Nov 1;68(21):8881-8. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 775.9±60.0 °C at 760 mmHg |
| Molecular Formula | C34H44O13 |
| Molecular Weight | 660.705 |
| Flash Point | 242.4±26.4 °C |
| Exact Mass | 660.278198 |
| PSA | 195.49000 |
| LogP | 1.88 |
| Vapour Pressure | 0.0±6.0 mmHg at 25°C |
| Index of Refraction | 1.604 |
| InChIKey | FFQOXBQSZPYHSA-MPOUNFKCSA-N |
| SMILES | CC(=O)OC1C(OC(C)=O)C2(C)C(C(O)C3C2C(C)C=C2OC(=O)C(C)(O)C23C)C2C(O)C(=O)C3CC4OC4C(OC(C)=O)C3(C)C12 |
Synonyms
| 1H-Oxireno[6',7']naphtho[1',2':7,8]fluoreno[2,1-b]furan-4,8-dione, 11,12,13-tris(acetyloxy)-5,5a,5b,6,6a,6b,7,8a,9,9a,10a,11,11a,11b,12,13,13a,13b-octadecahydro-5,6,7-trihydroxy-1,5,5a,11a,13a-pentamethyl-, (1S,5S,5aS,5bR,6R,6aS,6bS,7R,8aS,9aS,10aS,11R,11aR,11bS,12S,13R,13aR,13bS)- |
| (1S,5S,5aS,5bR,6R,6aS,6bS,7R,8aS,9aS,10aS,11R,11aR,11bS,12S,13R,13aR,13bS)-5,6,7-Trihydroxy-1,5,5a,11a,13a-pentamethyl-4,8-dioxo-4,5,5a,5b,6,6a,6b,7,8,8a,9,9a,10a,11,11a,11b,12,13,13a,13b-icosahydro-1H-oxireno[6',7']naphtho[1',2':7,8]fluoreno[2,1-b]furan-11,12,13-triyl triacetate |
