CAS 55721-11-4|Secalciferol
| Common Name | Secalciferol | ||
|---|---|---|---|
| CAS Number | 55721-11-4 | Molecular Weight | 416.637 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 571.1±35.0 °C at 760 mmHg |
| Molecular Formula | C27H44O3 | Melting Point | 63-65ºC |
| MSDS | ChineseUSA | Flash Point | 241.5±20.5 °C |
| Symbol | GHS06, GHS08 | Signal Word | Danger |
Names
| Name | (24R)-24,25-dihydroxycalciol |
|---|---|
| Synonym | More Synonyms |
Secalciferol BiologicalActivity
| Description | Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification. IC50 value:Target: In addition, it is known that Secalciferol mediates calcium and phosphorus homeostasis. Also Secalciferol inhibits calcium channels in osteosarcoma cells via suppressing the effects of 1α, 25-dihydroxyvitamin D3 and testosterone. Alternate studies indicate that Secalciferol can decrease the abundance of p53 and Pi-induced cytochrome c translocation. Furthermore, Secalciferol can increase cell proliferation in resting zone (RC) chondrocytes and inhibits matrix enzymes by possibly inhibiting the degradation of the matrix. |
|---|---|
| Related Catalog | Signaling Pathways >>Vitamin D Related >>VD/VDRResearch Areas >>Inflammation/Immunology |
| References | [1]. Yamamoto T, Ozono K, Shima M, et al. 24R,25-dihydroxyvitamin D3 increases cyclic GMP contents, leading to an enhancement of osteocalcin synthesis by 1,25-dihydroxyvitamin D3 in cultured human osteoblastic cells. Exp Cell Res. 1998 Oct 10;244(1):71-6. [2]. Sakaki T, Sawada N, Takeyama K, et al. Enzymatic properties of mouse 25-hydroxyvitamin D3 1 α-hydroxylase expressed in Escherichia coli. Eur J Biochem. 1999 Feb;259(3):731-8. [3]. Norman AW, Okamura WH, Bishop JE, Henry HL. Update on biological actions of 1α,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3. Mol Cell Endocrinol. 2002 Nov 29;197(1-2):1-13 [4]. Hurst-Kennedy J, Zhong M, Gupta V et al. 24R,25-Dihydroxyvitamin D3, lysophosphatidic acid, and p53: a signaling axis in the inhibition of phosphate-induced chondrocyte apoptosis. J Steroid Biochem Mol Biol. 2010 Oct;122(4):264-71. [5]. Wehmeier KR, Alamir AR, Sultan S, et al. 24, 25-dihydroxycholecalciferol but not 25-hydroxycholecalciferol suppresses apolipoprotein A-I gene expression. Life Sci. 2011 Jan 3;88(1-2):110-6. [6]. Rubin LP, Yeung B, Vouros P et al. Evidence for human placental synthesis of 24,25-dihydroxyvitamin D3 and 23,25-dihydroxyvitamin D3. Pediatr Res. 1993 Jul;34(1):98-104. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 571.1±35.0 °C at 760 mmHg |
| Melting Point | 63-65ºC |
| Molecular Formula | C27H44O3 |
| Molecular Weight | 416.637 |
| Flash Point | 241.5±20.5 °C |
| Exact Mass | 416.329041 |
| PSA | 60.69000 |
| LogP | 5.85 |
| Vapour Pressure | 0.0±3.6 mmHg at 25°C |
| Index of Refraction | 1.547 |
| InChIKey | FCKJYANJHNLEEP-BYHBPXLLSA-N |
| SMILES | C=C1CCC(O)CC1=CC=C1CCCC2(C)C1CCC2C(C)CCC(O)C(C)(C)O |
| Storage condition | 2-8℃ |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #94-247858
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #94-247858
Safety Information
| Symbol | GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 + H311-H330-H372 |
| Precautionary Statements | P260-P280-P284-P301 + P310-P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T+:Verytoxic; |
| Risk Phrases | R28 |
| Safety Phrases | S28-S36/37-S45 |
| RIDADR | UN 2811 |
| RTECS | VS2895000 |
Articles33
More Articles| Interdependence and contributions of sun exposure and vitamin D to MRI measures in multiple sclerosis. J. Neurol. Neurosurg. Psychiatr. 84(10) , 1075-81, (2013) To assess the relationships of sun exposure history, supplementation and environmental factors to vitamin D levels in multiple sclerosis (MS) patients and to evaluate the associations between sun expo... | |
| Dietary vitamin D inadequacy accelerates calcification and osteoblast-like cell formation in the vascular system of LDL receptor knockout and wild-type mice. J. Nutr. 144(5) , 638-46, (2014) Vitamin D insufficiency is highly associated with cardiovascular morbidity and mortality. We have demonstrated enhanced vascular calcification in LDL receptor knockout (LDLR(-/-)) mice fed a diet low ... | |
| Anti-inflammatory effect of vitamin D on gingivitis: a dose-response randomised control trial. Oral Health Prev. Dent. 11(1) , 61-9, (2013) To assess the anti-inflammatory effect of vitamin D on gingivitis at various doses.In this randomized controlled trial, daily oral vitamin D supplementation was given in doses of 2000 IU for group A, ... |
Synonyms
| k-dr |
| (3S,5Z,7E,14β,24R)-9,10-Secocholesta-5,7,10-triene-3,24,25-triol |
| Secalciferol |
| 2,3-Heptanediol, 2-methyl-6-[(1R,3aR,4E,7aR)-octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-7a-methyl-1H-inden-1-yl]-, (3R,6R)- |
| osteod |
