Introduction：Basic information about CAS 603-41-8|Desacetyl Bisacodyl, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Desacetyl Bisacodyl |
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| CAS Number | 603-41-8 | Molecular Weight | 277.32 |
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| Density | 1.244g/cm3 | Boiling Point | 462.1ºC at 760 mmHg |
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| Molecular Formula | C18H15NO2 | Melting Point | >200ºC (dec.) |
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| MSDS | / | Flash Point | 233.3ºC |
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Names
| Name | 4-[(4-hydroxyphenyl)-pyridin-2-ylmethyl]phenol |
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| Synonym | More Synonyms |
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Desacetyl Bisacodyl BiologicalActivity
| Description | Desacetyl bisacodyl is the active metabolite of the laxative bisacodyl. Desacetyl bisacodyl induces epithelial Cl(-) secretion in rat colon and rectum. Desacetyl bisacodyl evokes several effects at the colon or rectum, including increased mucus and chloride secretion[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
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| References | [1]. Fujita T, et, al. Desacetyl bisacodyl-induced epithelial Cl(-) secretion in rat colon and rectum. Biomed Res. 2016;37(1):13-20. |
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Chemical & Physical Properties
| Density | 1.244g/cm3 |
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| Boiling Point | 462.1ºC at 760 mmHg |
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| Melting Point | >200ºC (dec.) |
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| Molecular Formula | C18H15NO2 |
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| Molecular Weight | 277.32 |
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| Flash Point | 233.3ºC |
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| Exact Mass | 277.11000 |
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| PSA | 53.35000 |
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| LogP | 3.67300 |
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| Index of Refraction | 1.655 |
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| InChIKey | LJROKJGQSPMTKB-UHFFFAOYSA-N |
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| SMILES | Oc1ccc(C(c2ccc(O)cc2)c2ccccn2)cc1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- SM8730000
- CHEMICAL NAME :
- Phenol, 4,4'-(2-pyridylmethylene)di-
- CAS REGISTRY NUMBER :
- 603-41-8
- BEILSTEIN REFERENCE NO. :
- 0212040
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C18-H15-N-O2
- MOLECULAR WEIGHT :
- 277.34
- WISWESSER LINE NOTATION :
- T6NJ BYR DQ&R DQ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8550 mg/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association. (Nara Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken, Japan) V.1- 1950- Volume(issue)/page/year: 28,258,1977
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| 4,4'-pyridin-2-ylmethanediyl-bis-phenol |
| EINECS 210-039-7 |
| Deacetylbisocodyl |
| DDPM |
| La-96 |
| deacetylbisacodyl |
| Dihydroxydiphenyl-pyridyl methane |
