CAS 2886-65-9|N-Desalkylflurazepam

Introduction：Basic information about CAS 2886-65-9|N-Desalkylflurazepam, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Articles23
7. Synonyms

Common Name	N-Desalkylflurazepam
CAS Number	2886-65-9	Molecular Weight	288.704
Density	1.4±0.1 g/cm3	Boiling Point	463.5±55.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₀ClFN₂O	Melting Point	204-206°C
MSDS	ChineseUSA	Flash Point	234.1±31.5 °C
Symbol	GHS02, GHS06, GHS08	Signal Word	Danger

Names

Name	7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	463.5±55.0 °C at 760 mmHg
Melting Point	204-206°C
Molecular Formula	C₁₅H₁₀ClFN₂O
Molecular Weight	288.704
Flash Point	234.1±31.5 °C
Exact Mass	288.046570
PSA	41.46000
LogP	2.40
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.648
InChIKey	UVCOILFBWYKHHB-UHFFFAOYSA-N
SMILES	O=C1CN=C(c2ccccc2F)c2cc(Cl)ccc2N1
Storage condition	-20°C Freezer

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DF2370100

CHEMICAL NAME :: 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-

CAS REGISTRY NUMBER :: 2886-65-9

BEILSTEIN REFERENCE NO. :: 0754061

LAST UPDATED :: 199706

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H10-Cl-F-N2-O

MOLECULAR WEIGHT :: 288.72

WISWESSER LINE NOTATION :: T67 GMV JN IHJ CG KR BF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 26RAAN "Benzodinzenines," Garattini, S., et al., New York, Raven Press, 1973 Volume(issue)/page/year: -,46,1973

Safety Information

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	F,T
Risk Phrases	11-23/24/25-39/23/24/25
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	DF2370100
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles23

Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs.

Xenobiotica 44(10) , 893-901, (2014)

1. The pharmacokinetics of acetaminophen (marker of gastric emptying), antipyrine (marker of hepatic metabolic activity and total body water), diazepam (lipophilic and highly distributed), diphenhydra...

Cleaning up blood samples using a modified "QuEChERS" procedure for the determination of drugs of abuse and benzodiazepines by UPLC-MSMS(☆).

Forensic Sci. Int. 243 , 99-106, (2014)

The "QuEChERS" (quick, easy, cheap, effective, rugged, and safe) dispersive SPE (dSPE) method is an emerging sample preparation technique that is becoming increasingly popular in the area of multi-res...

Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samples

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014)

• The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail.

Synonyms

Norfludiazepam

N-Desalkylflurazepam

Ro 5-3367

Norflutoprazepam

7-Chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-ol

2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-

7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

7-chloro-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one

2H-1,4-BENZODIAZEPIN-2-ONE,1,3-DIHYDRO-7-CHLORO-5-(2-FLUOROPHENYL)

EINECS 220-748-3

5-(2-Fluorophenyl)-7-chloro-1,4-benzodiazepin-2-one

Dealkylflurazepam

nor-Flurazepam

MFCD00083443

CM 7116

7-Chloro-5-(2-fluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

N-DESALKYL-2-OXOQUAZEPAM

7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2(2H)-one

Descarbethoxyloflazepate

3H-1,4-Benzodiazepin-2-ol, 7-chloro-5-(2-fluorophenyl)-

7-chloro-5-(2-fluorophenyl)-1,3-dihydrobenzo[e][1,4]diazepin-2-one

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