CAS 531-85-1|Benzidine dihydrochloride
Introduction：Basic information about CAS 531-85-1|Benzidine dihydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Benzidine dihydrochloride | ||
|---|---|---|---|
| CAS Number | 531-85-1 | Molecular Weight | 257.15900 |
| Density | 1.156g/cm3 | Boiling Point | >402ºC |
| Molecular Formula | C12H14Cl2N2 | Melting Point | ≥300 °C |
| MSDS | ChineseUSA | Flash Point | 203.5ºC |
| Symbol | GHS07, GHS08, GHS09 | Signal Word | Danger |
Names
| Name | Benzidine dihydrochloride |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Density | 1.156g/cm3 |
|---|---|
| Boiling Point | >402ºC |
| Melting Point | ≥300 °C |
| Molecular Formula | C12H14Cl2N2 |
| Molecular Weight | 257.15900 |
| Flash Point | 203.5ºC |
| Exact Mass | 256.05300 |
| PSA | 52.04000 |
| LogP | 5.28440 |
| InChIKey | RUAXWVDEYJEWRY-UHFFFAOYSA-N |
| SMILES | Cl.Cl.Nc1ccc(-c2ccc(N)cc2)cc1 |
| Water Solubility | 0.1-0.5 g/100 mL at 23.5 ºC |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 62 mg/kg/4W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Endocrine - tumors Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3360 mg/kg/80W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 75 mg/kg/3Y-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1600 mg/kg/84W-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Endocrine - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5040 mg/kg/60W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8064 mg/kg/80W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1680 mg/kg/40W-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 13440 mg/kg/1Y-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
- TYPE OF TEST :
- DNA damage
- TYPE OF TEST :
- DNA damage
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Sister chromatid exchange
- TYPE OF TEST :
- Sister chromatid exchange
MUTATION DATA - TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 20 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 94,449,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83072 No. of Facilities: 64 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 598 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83072 No. of Facilities: 103 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 2987 (estimated) No. of Female Employees: 2464 (estimated)
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 20 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 94,449,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83072 No. of Facilities: 64 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 598 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83072 No. of Facilities: 103 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 2987 (estimated) No. of Female Employees: 2464 (estimated)
Safety Information
| Symbol | GHS07, GHS08, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H350-H410 |
| Precautionary Statements | P201-P273-P308 + P313-P501 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic;N:Dangerousfortheenvironment; |
| Risk Phrases | R45;R22;R50/53 |
| Safety Phrases | S53-S45-S60-S61 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | DD0600000 |
| HS Code | 2921590090 |
Customs
| HS Code | 2921590090 |
|---|---|
| Summary | 2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| Benzidine Dihydrochloride |
| EINECS 208-519-6 |
| 4-(4-aminophenyl)aniline,dihydrochloride |
| MFCD00040389 |
