CAS 108-23-6|Isopropyl chloroformate

Introduction：Basic information about CAS 108-23-6|Isopropyl chloroformate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Articles4
7. Synonyms

Common Name	Isopropyl chloroformate
CAS Number	108-23-6	Molecular Weight	122.550
Density	1.1±0.1 g/cm3	Boiling Point	108.3±9.0 °C at 760 mmHg
Molecular Formula	C₄H₇ClO₂	Melting Point	-81ºC
MSDS	Chinese	Flash Point	25.0±11.8 °C
Symbol	GHS02, GHS05, GHS06, GHS08	Signal Word	Danger

Names

Name	Isopropyl Chloroformate
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	108.3±9.0 °C at 760 mmHg
Melting Point	-81ºC
Molecular Formula	C₄H₇ClO₂
Molecular Weight	122.550
Flash Point	25.0±11.8 °C
Exact Mass	122.013458
PSA	26.30000
LogP	1.79
Vapour Pressure	26.1±0.2 mmHg at 25°C
Index of Refraction	1.409
InChIKey	IVRIRQXJSNCSPQ-UHFFFAOYSA-N
SMILES	CC(C)OC(=O)Cl

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LQ6475000

CHEMICAL NAME :: Formic acid, chloro-, isopropyl ester

CAS REGISTRY NUMBER :: 108-23-6

BEILSTEIN REFERENCE NO. :: 0506416

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C4-H7-Cl-O2

MOLECULAR WEIGHT :: 122.56

WISWESSER LINE NOTATION :: GVOY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. (Pittsburgh, PA) 1947-69. Volume(issue)/page/year: 6,1,1967

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. (Pittsburgh, PA) 1947-69. Volume(issue)/page/year: 6,1,1967 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1070 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. (Pittsburgh, PA) 1947-69. Volume(issue)/page/year: 6,1,1967

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 ppm/5H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 27,1,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 178 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978 Volume(issue)/page/year: 4,758,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978 Volume(issue)/page/year: 4,758,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 11300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. (Pittsburgh, PA) 1947-69. Volume(issue)/page/year: 6,1,1967 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 ppm/6H/2W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Blood - hemorrhage Related to Chronic Data - death

REFERENCE :: BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 27,1,1970 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 1 ppm (5 mg/m3) JAN 1993

Safety Information

Symbol	GHS02, GHS05, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H304-H314-H317-H330-H336-H361d-H373
Precautionary Statements	P210-P260-P280-P284-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	F:Flammable;C:Corrosive;
Risk Phrases	R11;R34;R48/20;R63;R65;R67
Safety Phrases	S26-S36/37/39-S45-S62
RIDADR	UN 3286 3/PG 2
WGK Germany	2
RTECS	LQ6475000
Packaging Group	I
Hazard Class	6.1(a)
HS Code	2915130000

Customs

HS Code	2915900090
Summary	2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Articles4

Dual element ((15)N/(14)N, (13)C/(12)C) isotope analysis of glyphosate and AMPA by derivatization-gas chromatography isotope ratio mass spectrometry (GC/IRMS) combined with LC/IRMS.

Anal. Bioanal. Chem 407 , 5249-60, (2015)

To assess sources and degradation of the herbicide glyphosate [N-(phosphonomethyl) glycine] and its metabolite AMPA (aminomethylphosphonic acid), concentration measurements are often inconclusive and ...

Friedel-Crafts Alkylation of Alkenes: Ethylaluminum Sesquichloride Induced Alkylations with Alkyl Chloroformates.

Angew. Chem. Int. Ed. Engl. 38(24) , 3675-3677, (1999)

The formal addition of propane to nonactivated double bonds can be achieved with isopropyl chloroformate (2) in the presence of Et(3)Al(2)Cl(3). Thus, a 1:1 mixture of 10-isopropyloctadecanoic acid (3...

Grunwald-Winstein analysis: isopropyl chloroformate solvolysis revisited.

Int. J. Mol. Sci. 10(3) , 862-79, (2009)

Specific rates of solvolysis at 25 degrees C for isopropyl chloroformate (1) in 24 solvents of widely varying nucleophilicity and ionizing power, plus literature values for studies in water and formic...

Synonyms

EINECS 203-563-2

Chloroformic Acid Isopropyl Ester

propan-2-yl carbonochloridate

1-methylethyl chlorocarbonate

Isopropyl carbonochloridate

MFCD00075068

Carbonochloridic acid, 1-methylethyl ester

Isopropyl chloroformate

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